32147-20-9

Basic information

• Product Name: (2Z)-2-bromo-1,3-diphenylprop-2-en-1-one
• Synonyms: .alpha.-Bromochalcone; 2-Propen-1-one, 2-bromo-1,3-diphenyl-; Chalcone, .alpha.-bromo-
• CAS NO: 32147-20-9
• Molecular Formula: C₁₅H₁₁BrO
• Molecular Weight: 287.1512
• Mol File: 32147-20-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 386.5°C at 760 mmHg
• Flash Point: 71.3°C
• Density: 1.415g/cm³
• Vapor Pressure: 3.51E-06mmHg at 25°C
• Refractive Index: 1.657
• CAS DataBase Reference: (2Z)-2-bromo-1,3-diphenylprop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2Z)-2-bromo-1,3-diphenylprop-2-en-1-one(32147-20-9)
• EPA Substance Registry System: (2Z)-2-bromo-1,3-diphenylprop-2-en-1-one(32147-20-9)

Safety Data

• Hazardous Substances Data: 32147-20-9(Hazardous Substances Data)

Usage

General Description

(2Z)-2-bromo-1,3-diphenylprop-2-en-1-one is a chemical compound with the molecular formula C15H11BrO. It is a yellow solid that is soluble in organic solvents. (2Z)-2-bromo-1,3-diphenylprop-2-en-1-one is a chalcone derivative, which is a type of organic compound that contains an enone group. It is commonly used in organic synthesis and medicinal chemistry as a precursor for the synthesis of various pharmaceuticals and biologically active compounds. The presence of the bromine atom and the phenyl groups in the molecule may impart specific properties and reactivity to this compound, making it useful in a variety of research and industrial applications.

Upstream product

• 611-91-6 rac-(S,S)-2,3-dibromo-1,3-diphenylpropan-1-one 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 611-91-6 2,3-dibromo-1,3-diphenylpropane-1-one 
• 94-41-7 benzalacetophenone 
• 100-52-7 benzaldehyde 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 98-86-2 acetophenone 

Downstream Products

• 5073-08-5 2-bromo-3-morpholin-4-yl-1,3-diphenyl-propan-1-one 
• 611-91-6 trans-2,3-dibromo-1,3-diphenylpropan-1-one 
• 101009-45-4 (E)-3-methoxy-1,3-diphenylprop-2-en-1-one 
• 1666-86-0 2,4,6-triphenylpyrimidine 
• 1145-01-3 3,5-Diphenylpyrazole 
• 32147-19-6 (E)-2-bromo-1,3-diphenylprop-2-en-1-one 
• 2211-61-2 ((2S,3S)-1-Cyclohexyl-3-phenyl-aziridin-2-yl)-phenyl-methanone 
• 119-80-2 2,2'-dithiobenzoic acid 
• 2183-27-9 1,3,5-triphenyl-1H-pyrazole 
• 854678-58-3 3-(benzyl-methyl-amino)-2-bromo-1,3-diphenyl-propan-1-one 
• 856073-08-0 2-bromo-3-benzenesulfonyl-1,3-diphenyl-propan-1-one 
• 72997-93-4 1-benzyl-2-benzoyl-3-phenylaziridine 
• 6372-57-2 (2S*,3S*)-2-benzoyl-1-benzyl-3-(phenyl)azidridine 

Relevant articles and documents

Modular access to 1,2-allenyl ketones based on a photoredox-catalysed radical-polar crossover process

Herein, a new protocol dealing with the preparation of 1,2-allenyl ketones has been successfully developedviathe reactions of enynes with radicals enabled by dual photoredox/copper catalysis. Based on the results of a deuteration experiment and the competition reaction between cyclopropanation and allenation, the mechanism based on a photoredox-neutral-catalysed radical-polar crossover process has been proposed. Synthetic applications of allenes have also been demonstrated.

Synthesis method of Z-type halogenated chalcone compound

The invention relates to a synthesis method of a Z-type halogenated chalcone compound as shown in formula (III), characterized by comprising: by using a compound shown in formula (I) and a compound shown in formula (II) as reaction raw materials, using IPrAuCl as a catalyst, using AgSbF as an assistant and using 1,2-dichloroethane as a solvent, performing a reaction at the room temperature; andafter ending the reaction, carrying out post treatment on reaction liquid to obtain the Z-type halogenated chalcone compound as shown in formula (III). The synthesis method disclosed by the inventionis simple and short in step, mild in condition, very high in reaction speed, meanwhile, high in yield and good in regioselectivity, and is a green and economic reaction process; (The formulas are shown in the description.).

Nucleophilic substitution of α-haloenones with phenols

The α-haloenones undergo cine-substitution upon reaction with phenolic reagents under basic conditions. A convenient method for the synthesis of push-pull aroxyenones was developed based on this reaction.