32157-73-6

Basic information

• Product Name: Methanone, (4-chlorophenyl)[(2R,3S)-3-phenyloxiranyl]-, rel-
• CAS NO: 32157-73-6
• Molecular Formula: C15H11ClO2
• Molecular Weight: 258.704
• Mol File: 32157-73-6.mol
• Article Data: 62

Chemical Properties

• CAS DataBase Reference: Methanone, (4-chlorophenyl)[(2R,3S)-3-phenyloxiranyl]-, rel-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (4-chlorophenyl)[(2R,3S)-3-phenyloxiranyl]-, rel-(32157-73-6)
• EPA Substance Registry System: Methanone, (4-chlorophenyl)[(2R,3S)-3-phenyloxiranyl]-, rel-(32157-73-6)

Safety Data

• Hazardous Substances Data: 32157-73-6(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 937-20-2 p-chlorophenacyl chloride 
• 956-02-5 4'-chlorochalcone 
• 22966-22-9 (E)-1-(4-chlorophenyl)-3-phenyl-2-propen-1-one 
• 124-38-9 carbon dioxide 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 99-91-2 para-chloroacetophenone 
• 100-42-5 styrene 
• 104-88-1 4-chlorobenzaldehyde 
• 14531-55-6 3,5-dimethyl-4-nitro-1H-pyrazole 
• 32157-73-6 1-(p-chlorophenyl)-2,3-epoxy-3-phenylpropan-1-one 
• 532-27-4 1-chloroacetophenone 

Downstream Products

• 32157-73-6 trans-(2R,3S)-2,3-epoxy-3-phenyl-1-(4-chlorophenyl)propan-1-one 
• 30152-32-0 3-(4?'-chlorophenyl)-5-phenyl-1H-pyrazole 
• 67295-28-7 1-(4-chloro-phenyl)-2-hydroxy-3-morpholin-4-yl-3-phenyl-propan-1-one 
• 17059-59-5 1-(4-chloro-phenyl)-3-phenyl-propane-1,3-dione 
• 956-02-5 4'-chlorochalcone 
• 127634-34-8 O-Acetyl-4'-chlor-chalkonbromhydrin 
• 51679-64-2 3-Chloro-1-(4-chloro-phenyl)-2-hydroxy-3-phenyl-propan-1-one 
• 99430-31-6 1-(4-Chloro-phenyl)-3-fluoro-2-hydroxy-3-phenyl-propan-1-one 
• 127634-32-6 3-Bromo-1-(4-chloro-phenyl)-2-hydroxy-3-phenyl-propan-1-one 
• 132455-50-6 (2S,3R)-3-Phenyl-oxirane-2-carboxylic acid 4-chloro-phenyl ester 
• 132455-54-0 4-Chloro-benzoic acid formyloxy-phenyl-methyl ester 

Relevant articles and documents

A high-yielding protocol for the synthesis of 4,5-diarylpyrimidin-2-amine derivatives from chalcones

A novel, high yielding and versatile protocol was achieved for the synthesis of 4,5-diaryl-2-pyrimidinamine derivatives from chalcones. The synthesis was accomplished by converting the chalcones into 3-chloro-2,3-diaryl-2-propen-1-ones followed by subsequent reaction with amidine derivatives.

Asymmetric epoxidation of α,β-unsaturated ketones via an amine-thiourea dual activation catalysis

A simple asymmetric epoxidation method is developed to effectively synthesize chiral α-carbonyl epoxides through an amine-thiourea dual activation catalysis. In this method, TBHP, as an oxidant, determined the reaction rate, and the chiral amine-thiourea catalyst effectively controlled the stereoselectivity of the reaction, and KOH promoted deprotonation. 22 examples of α,β-unsaturated ketones with various substituent groups are smoothly converted into α-carbonyl epoxides with moderate to excellent enantiomeric excess.

Highly Enantioselective Epoxidation of α,β-Unsaturated Ketones Using Amide-Based Cinchona Alkaloids as Hybrid Phase-Transfer Catalysts

A series of 20 one chiral epoxides were obtained with excellent yields (up to 99%) and enantioselectivities (up to >99% ee) using hybrid amide-based Cinchona alkaloids. Our method is characterized by low catalyst loading (0.5 mol %) and short reaction times. Moreover, the epoxidation process can be carried out in 10 cycles, without further catalyst addition to the reaction mixture. This methodology significantly enhance the scale of the process using very low catalyst loading.