323-91-1

Basic information

• Product Name: 2-(4-FLUOROPHENYL)QUINOLINE
• Synonyms: 2-(4-FLUOROPHENYL)QUINOLINE
• CAS NO: 323-91-1
• Molecular Formula: C₁₅H₁₀FN
• Molecular Weight: 223.25
• Mol File: 323-91-1.mol
• Article Data: 96

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-FLUOROPHENYL)QUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-FLUOROPHENYL)QUINOLINE(323-91-1)
• EPA Substance Registry System: 2-(4-FLUOROPHENYL)QUINOLINE(323-91-1)

Safety Data

• Hazardous Substances Data: 323-91-1(Hazardous Substances Data)

Usage

General Description

2-(4-Fluorophenyl)quinoline is a chemical compound with the formula C16H11FN. It is a derivative of quinoline, a heterocyclic aromatic compound. This molecule consists of a quinoline core with a 4-fluorophenyl group attached at the 2-position. It is a yellowish crystalline powder that is sparingly soluble in water, but soluble in organic solvents. 2-(4-FLUOROPHENYL)QUINOLINE is used in the laboratory as a building block for the synthesis of various organic compounds. It is also of interest in medicinal chemistry research, with potential applications in the development of pharmaceuticals. The 4-fluorophenyl group can influence the physical and chemical properties of the quinoline core, making this compound a versatile starting material for the production of new molecules with specific properties and potential uses.

Upstream product

• 441-28-1 2-(4-fluorophenyl)-quinoline-4-carboxylic acid 
• 5344-90-1 2-Aminobenzyl alcohol 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 403-41-8 1-(4-Fluorophenyl)ethanol 
• 615-43-0 2-iodophenylamine 
• 3798-61-6 1-(4-fluorophenyl)prop-2-yn-1-ol 
• 3792-93-6 (E)-1-(4-fluorophenyl)-3-(2-nitrophenyl)prop-2-en-1-one 
• 552-89-6 2-nitro-benzaldehyde 
• 462-06-6 fluorobenzene 
• 91-56-5 indole-2,3-dione 
• 91-22-5 quinoline 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 1765-93-1 4-fluoroboronic acid 
• 456-03-1 1-(4-fluorophenyl)propan-1-one 

Downstream Products

• 1016275-44-7 (S)-2-(4-fluorophenyl)-1,2,3,4-tetrahydroquinoline(S)-2-(4-fluorophenyl)-1,2,3,4-tetrahydroquinoline 
• 1190876-74-4 (R)-2-(4-fluorophenyl)-1,2,3,4-tetrahydroquinoline 
• 1402568-43-7 (±)-2-(4-fluorophenyl)-1,2,3,4-tetrahydroquinoline 
• 941670-63-9 2-(4-fluorophenyl)-4-methylquinoline 

Relevant articles and documents

Visible-Light-Mediated Oxidative Cyclization of 2-Aminobenzyl Alcohols and Secondary Alcohols Enabled by an Organic Photocatalyst

This paper describes a visible-light-mediated oxidative cyclization of 2-aminobenzyl alcohols and secondary alcohols to produce quinolines at room temperature. This photocatalytic method employed anthraquinone as an organic small-molecule catalyst and DMSO as an oxidant. According to this present procedure, a series of quinolines were prepared in satisfactory yields.

Designed pincer ligand supported Co(ii)-based catalysts for dehydrogenative activation of alcohols: Studies onN-alkylation of amines, α-alkylation of ketones and synthesis of quinolines

Base-metal catalystsCo1,Co2andCo3were synthesized from designed pincer ligandsL1,L2andL3having NNN donor atoms respectively.Co1,Co2andCo3were characterized by IR, UV-Vis. and ESI-MS spectroscopic studies. Single crystal X-ray diffraction studies were investigated to authenticate the molecular structures ofCo1andCo3. CatalystsCo1,Co2andCo3were utilized to study the dehydrogenative activation of alcohols forN-alkylation of amines, α-alkylation of ketones and synthesis of quinolines. Under optimized reaction conditions, a broad range of substrates including alcohols, anilines and ketones were exploited. A series of control experiments forN-alkylation of amines, α-alkylation of ketones and synthesis of quinolines were examined to understand the reaction pathway. ESI-MS spectral studies were investigated to characterize cobalt-alkoxide and cobalt-hydride intermediates. Reduction of styrene by evolved hydrogen gas during the reaction was investigated to authenticate the dehydrogenative nature of the catalysts. Probable reaction pathways were proposed forN-alkylation of amines, α-alkylation of ketones and synthesis of quinolines on the basis of control experiments and detection of reaction intermediates.

Porous FeO(OH) Dispersed on Mg-Al Hydrotalcite Surface for One-Pot Synthesis of Quinoline Derivatives

The use of ubiquities elements such as iron instead of expensive precious metals as catalysts is one goal toward realizing environmentally benign synthetic chemistry. Here, we report that porous FeO(OH) dispersed on Mg?Al hydrotalcite acts as a bifunctional heterogeneous catalyst in the one-pot synthesis of 2-substituted quinoline derivatives through dehydrogenative oxidation-cyclization reactions. The catalyst was prepared by a simple grafting method using FeCl3 and Mg?Al hydrotalcite. The prepared porous FeO(OH) possesses a higher surface area than those previously reported for α-FeO(OH) particles. The one-pot quinoline synthesis proceeded effectively under non-noble-metal catalysis in air without requiring additional homogeneous bases or solvents.