330792-68-2

Basic information

• Product Name: Propanedinitrile, 2-[hydroxy(4-phenoxyphenyl)Methylene]-
• Synonyms: Propanedinitrile, 2-[hydroxy(4-phenoxyphenyl)Methylene]-;2-[Hydroxy-(4-phenoxy-phenyl)-Methylene]-Malononitrile;Propanedinitrile, 2-[hydroxy(4-phenoxyphenyl)Methylene]- 2-[Hydroxy-(4-phenoxy-phenyl)-Methylene]-Malononitrile
• CAS NO: 330792-68-2
• Molecular Formula: C₁₆H₁₀N₂O₂
• Molecular Weight: 262.2628
• Mol File: 330792-68-2.mol
• Article Data: 39

Chemical Properties

• Boiling Point: 415.3±45.0 °C(Predicted)
• Appearance: /
• Density: 1.279±0.06 g/cm3(Predicted)
• PKA: 4.65±0.50(Predicted)
• CAS DataBase Reference: Propanedinitrile, 2-[hydroxy(4-phenoxyphenyl)Methylene]-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedinitrile, 2-[hydroxy(4-phenoxyphenyl)Methylene]-(330792-68-2)
• EPA Substance Registry System: Propanedinitrile, 2-[hydroxy(4-phenoxyphenyl)Methylene]-(330792-68-2)

Safety Data

• Hazardous Substances Data: 330792-68-2(Hazardous Substances Data)

Usage

General Description

Propanedinitrile, 2-[hydroxy(4-phenoxyphenyl)methylene]- is a synthetic chemical compound commonly used in various industrial applications. It contains various chemical groups including a hydroxy group, a phenoxyphenyl group, and a methylene group attached to a propanedinitrile structure. Its unique chemical structure makes it useful in a variety of chemical reactions and processes. The specific properties like molecular weight, boiling point, melting point, and other physical and chemical properties of this compound will largely depend upon its precise molecular structure and the conditions under which it is used or stored. It is important to handle this and other industrial chemicals with care to protect human health and the environment.

Upstream product

• 1623-95-6 4-phenoxybenzoyl chloride 
• 109-77-3 malononitrile 
• 2215-77-2 4-Phenoxybenzoic acid 
• 21218-94-0 methyl 4-phenoxybenzoate 
• 619-44-3 methyl 4-iodobenzoate 
• 108-95-2 phenol 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 330792-69-3 2-[(4-phenoxy-phenyl)-methoxy-methylene]-malononitrile 
• 330786-24-8 3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 
• 936563-87-0 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one 
• 936563-86-9 tert-butyl 3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate 
• 1609467-43-7 benzyl 3-[5-amino-4-cyano-3-(4-phenoxy-phenyl)-pyrazol-1-yl]-piperidine-1-carboxylate 
• 1609467-44-8 5-amino-3-(4-phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazole-4-carbonitrile 
• 1609467-45-9 5-amino-3-(4-phenoxyphenyl)-1-piperidin-3-yl-1H-pyrazole-4-carboxylic acid amide 
• 1609465-64-6 5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazole carboxamide 
• 1609468-23-6 (S)-5-amino-3-(4-phenoxyphenyl)-1-piperidin-3-yl-1H-pyrazole-4-carboxylic acid amide 
• 1609467-02-8 1-[(3S)-1-acryloylpiperidin-3-yl]-5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide 
• 1558038-42-8 (R)-5-amino-3-(4-phenoxyphenyl)-1-piperidin-3-yl-1H-pyrazole-4-carboxylic acid amide 
• 1558036-85-3 1-[(3R)-1-acryloylpiperidin-3-yl]-5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide 
• 1609467-03-9 5-amino-1-{1-[(2E)-but-2-enoyl]piperidin-3-yl}-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide 
• 1609467-04-0 5-amino-1-{(3R)-1-[(2E)-4-hydroxybut-2-enoyl]piperidin-3-yl}-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide 

Relevant articles and documents

PROCESSES AND INTERMEDIATES FOR PREPARING A BTK INHIBITOR

Disclosed is a process for the preparation of certain intermediates, e.g. process for preparing a compound of formula (I) or a pharmaceutically acceptable salt thereof, in an enantioenriched form, which intermediate and processes are useful in the preparation of a BTK inhibitor, such as ibrutinib.

Therapeutic Combinations of a Proteasome Inhibitor and a BTK Inhibitor

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USE OF A COMBINATION COMPRISING A BTK INHIBITOR FOR TREATING CANCERS

A method for the prevention, delay of progression or treatment of cancer in a subject, comprising administering to the subject in need thereof a Btk inhibitor, particularly, (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide or a pharmaceutically acceptable salt thereof, in combination with an immune checkpoint inhibitor or a targeted therapy agent. A pharmaceutical combination comprising a Btk inhibitor, particularly, (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide or a pharmaceutically acceptable salt thereof, in combination with an immune checkpoint inhibitor or a targeted therapy agent.