330786-24-8 Usage
Description
5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMine is a chemical compound that serves as an intermediate in the synthesis of various pharmaceuticals, particularly Ibrutinib. It is an organic synthesis intermediate with potential applications in the development of new drugs and chemical compounds.
Uses
Used in Pharmaceutical Industry:
5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMine is used as an organic synthesis intermediate for the development of Ibrutinib (I124970), a highly selective Bruton’s tyrosine kinase (BTK) irreversible inhibitor. 5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMine plays a crucial role in the synthesis process, contributing to the creation of a drug that targets specific enzymes involved in various diseases.
Used in Chemical Production:
5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMine is also used as a pharmaceutical intermediate in chemical production processes. Its role extends beyond the synthesis of Ibrutinib, as it can be utilized in the development of other pharmaceutical compounds, enhancing the range of potential applications in the medical field.
Used in Laboratory Research and Development:
5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMine is employed in laboratory settings for research and development purposes. It aids scientists in understanding the properties and potential applications of Ibrutinib and other related compounds, contributing to the advancement of pharmaceutical research and the discovery of new drugs.
Synthesis
2 g of 3-iodo-4-aminopyrazolo[3,4-d]pyrimidine (7.7 mmol),3.28 g p-phenoxybenzeneboronic acid (15.4 mmol)And 5.28 g of K3PO4 (23.0 mmol) were dissolved in 25 mL of dioxane and 10 mL of water.After stirring for 5-8 minutes, argon gas was passed for 20 minutes.An additional 1.4 g of tetrakis(triphenylphosphine)palladium (1.2 mmol) was added.After heating again for 10 minutes, the heating was started, and the reaction was carried out at 120 ° C for 24 hours.After the reaction was completed, it was cooled to room temperature, stirred for 24 hours to wait for product to precipitate, and the reaction mixture was washed with 25 mL of water and filtered.The filtered solid was again washed with 75 ml of methanol, washed with 50 mL of ethanol, and dried in a dry box.There was obtained 1.75 g of 3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-4-amine in a yield of 75%.
Check Digit Verification of cas no
The CAS Registry Mumber 330786-24-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,3,0,7,8 and 6 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 330786-24:
(8*3)+(7*3)+(6*0)+(5*7)+(4*8)+(3*6)+(2*2)+(1*4)=138
138 % 10 = 8
So 330786-24-8 is a valid CAS Registry Number.
330786-24-8Relevant articles and documents
BENZENESULFONAMIDE DERIVATIVES AND USES THEREOF
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Paragraph 00210, (2021/02/12)
Provided herein are benzenesulfonamide derivatives having Formula (III), pharmaceutical compositions comprising said compounds, and method for using said compounds for disrupting proteins/polypeptides, protein/polypeptide function, and for the treatment of diseases through the disruption of proteins or polypeptides involved in the etiology of the disease. Said compounds comprise fluorinated benzene sulfonamide structures.
Preparation of key intermediate (by machine translation)
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Paragraph 0020-0021, (2020/09/12)
The invention belongs to the field of chemistry and relates to a preparation method of a key intermediate. The preparation method is simple in preparation steps, cheap and accessible in raw materials, free of precious metal reagents, and beneficial to industrial production. (by machine translation)
4 - Phenoxyphenyl pyrazolo pyrimidine amide derivatives and preparation method and application thereof (by machine translation)
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Paragraph 0068; 0117; 0118, (2020/06/17)
The invention provides a preparation method and application of 4 -phenoxyphenyl pyrazolo pyrimidine amide derivatives. The compound has the structure shown in the formula (I). Wherein X and Y are two linking groups, X is selected from benzyl, substituted benzyl, piperidinyl and C. 1 -6 Straight-chain or branched alkyl; Y is-(CH)2 )n - N is any integer selected from 0-4; R is selected from hydroxyl, hydroxyl and phthalo; the structure of formula (I) contains its racemates and stereoisomers. The compound has BTK K K K/HDAC double-target inhibition effect and growth inhibitory activity on T-cell leukemia cells and cell lymphoma cells, and is used for preparing antitumor drugs. (by machine translation)