33515-62-7

Basic information

• Product Name: SALOR-INT L164526-1EA
• Synonyms: SALOR-INT L164526-1EA;4-IODO-1H-PYRROLE-2-CARBALDEHYDE;4-iodo-1H-Pyrrole-2-carboxaldehyde;4-Iodopyrrole-2-carboxaldehyde
• CAS NO: 33515-62-7
• Molecular Formula: C₅H₄INO
• Molecular Weight: 221
• Mol File: 33515-62-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 117-118 °C(Solv: dichloromethane (75-09-2); hexane (110-54-3))
• Boiling Point: 319.3±27.0 °C(Predicted)
• Appearance: /
• Density: 2.177±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 13.70±0.50(Predicted)
• CAS DataBase Reference: SALOR-INT L164526-1EA(CAS DataBase Reference)
• NIST Chemistry Reference: SALOR-INT L164526-1EA(33515-62-7)
• EPA Substance Registry System: SALOR-INT L164526-1EA(33515-62-7)

Safety Data

• Hazardous Substances Data: 33515-62-7(Hazardous Substances Data)

Usage

General Description

SALOR-INT L164526-1EA is a chemical substance used for laboratory and research purposes. Its exact composition is not specified, but it is known to be a colorless to light yellow liquid with a specific gravity of approximately 0.92. It is also described as having a strong odor and a flash point of 60°C. This chemical may present a hazard if ingested, inhaled, or upon skin contact, and appropriate safety precautions should be taken when handling it. Overall, SALOR-INT L164526-1EA is a potentially hazardous substance that requires careful handling and storage.

Upstream product

• 1003-29-8 2-pyrrole aldehyde 

Downstream Products

• 500780-79-0 4-propynylpyrrole-2-carbaldehyde 
• 940949-49-5 C₂₉H₂₇NO₆ 
• 940949-50-8 1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-4-prop-1-ynyl-1H-pyrrole-2-carbaldehyde 
• 405219-18-3 1-diethoxymethyl-4-phenyl-1H-pyrrole-2-carbaldehyde 
• 1421837-01-5 1-(2,3,5-tri-O-benzyl-D-ribofuranosyl)-4-iodopyrrole-2-carbaldehyde 
• 1192718-89-0 7-phenyl-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine 
• 1192718-82-3 2-methyl-7-phenyl-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazine 
• 1192718-80-1 2-methyl-7-phenyl-1,2-dihydropyrrolo[1,2-a]pyrazin-3-one 
• 1192718-79-8 ethyl 2-(2-formyl-4-phenylpyrrol-1-yl)acetate 
• 1192718-86-7 2-(2-formyl-4-iodopyrrol-1-yl)ethyl 4-methylbenzenesulfonate 
• 1192718-87-8 2-(2-hydroxymethyl-4-iodopyrrol-1-yl)ethyl 4-methylbenzenesulfonate 

Relevant articles and documents

Synthesis method of 4-iodine-1H-pyrrole-2-formaldehyde

The invention relates to a synthesis method of 4-iodine-1H-pyrrole-2-formaldehyde, and the synthetic route is shown as the specification. The synthesis method includes: in a selected reaction solvent,reacting 1H-pyrrole-2-formaldehyde (1) with elemental iodine under the action of a selected inorganic base to generate 4-iodine-1H-pyrrole-2-formaldehyde (2); wherein the reaction solvent is any oneof N, N-dimethylformamide, N, N-dimethylacetamide and N-methyl pyrrolidone, and the inorganic base is one of lithium hydroxide, sodium hydroxide and potassium hydroxide.

An unnatural hydrophobic base, 4-propynylpyrrole-2-carbaldehyde, as an efficient pairing partner of 9-methylimidazo[(4,5)-b]pyridine

To develop unnatural base pairs that function in replication, we designed 4-propynylpyrrole-2-carbaldehyde (designated as Pa′) and synthesized the nucleoside derivatives of Pa′. The base pairing of Pa′ with the partner, 9-methylimidazo[(4,5)-b]pyridine (Q), was compared to that of pyrrole-2-carbaldehyde (Pa), which was previously developed as a specific pairing partner of Q. The thermal stability of a DNA duplex containing the Q-Pa′ pair and the incorporation efficiency of the Pa′ substrate (dPa′TP) into DNA opposite Q by the Klenow fragment of Escherichia coli DNA polymerase I were improved, in comparison with those of the Q-Pa pair. These improvements result from the increased hydrophobicity and stacking stability of Pa′ by the introduction of the propynyl group to Pa, providing valuable information for the further development of unnatural base pairs toward the expansion of the genetic alphabet.