500780-79-0 Usage
Molecular structure
1H-Pyrrole-2-carboxaldehyde, 4-(1-propynyl)-
The compound is a derivative of pyrrole, which is a five-membered aromatic ring containing a nitrogen atom. It has a propynyl group (a triple-bonded carbon and hydrogen chain) attached at the 4-position of the pyrrole ring.
Aromatic ring
Pyrrole
The compound contains a five-membered aromatic ring with a nitrogen atom, which contributes to its stability and chemical properties.
Propynyl group
1-propynyl
A triple-bonded carbon and hydrogen chain (-C≡CH) attached to the 4-position of the pyrrole ring, influencing the compound's unique structure and properties.
Functional groups
Carboxaldehyde and Alkyne
The compound contains a carboxaldehyde group (-CHO) at the 2-position of the pyrrole ring, which provides reactivity and allows for further chemical modifications. The propynyl group also contains an alkyne functional group (a carbon-carbon triple bond), which can participate in various chemical reactions.
Uses
Organic synthesis, pharmaceuticals, and agrochemicals
The compound is commonly used as a building block in the preparation of various pharmaceuticals and agrochemicals due to its versatile nature and reactivity.
Intermediate
Valuable in the production of a wide range of compounds
The compound serves as an important intermediate in the synthesis of numerous other chemical compounds, making it a valuable asset in the field of organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 500780-79-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,0,0,7,8 and 0 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 500780-79:
(8*5)+(7*0)+(6*0)+(5*7)+(4*8)+(3*0)+(2*7)+(1*9)=130
130 % 10 = 0
So 500780-79-0 is a valid CAS Registry Number.
500780-79-0Relevant articles and documents
An unnatural hydrophobic base, 4-propynylpyrrole-2-carbaldehyde, as an efficient pairing partner of 9-methylimidazo[(4,5)-b]pyridine
Mitsui, Tsuneo,Kimoto, Michiko,Sato, Akira,Yokoyama, Shigeyuki,Hirao, Ichiro
, p. 4515 - 4518 (2003)
To develop unnatural base pairs that function in replication, we designed 4-propynylpyrrole-2-carbaldehyde (designated as Pa′) and synthesized the nucleoside derivatives of Pa′. The base pairing of Pa′ with the partner, 9-methylimidazo[(4,5)-b]pyridine (Q), was compared to that of pyrrole-2-carbaldehyde (Pa), which was previously developed as a specific pairing partner of Q. The thermal stability of a DNA duplex containing the Q-Pa′ pair and the incorporation efficiency of the Pa′ substrate (dPa′TP) into DNA opposite Q by the Klenow fragment of Escherichia coli DNA polymerase I were improved, in comparison with those of the Q-Pa pair. These improvements result from the increased hydrophobicity and stacking stability of Pa′ by the introduction of the propynyl group to Pa, providing valuable information for the further development of unnatural base pairs toward the expansion of the genetic alphabet.
