940949-49-5

Basic information

• Product Name: C₂₉H₂₇NO₆
• CAS NO: 940949-49-5
• Molecular Weight: 485.536
• Mol File: 940949-49-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₉H₂₇NO₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₉H₂₇NO₆(940949-49-5)
• EPA Substance Registry System: C₂₉H₂₇NO₆(940949-49-5)

Safety Data

• Hazardous Substances Data: 940949-49-5(Hazardous Substances Data)

Upstream product

• 4330-21-6 2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride 
• 500780-79-0 4-propynylpyrrole-2-carbaldehyde 
• 33515-62-7 4-iodo-1H-pyrrole-2-carbaldhehyde 
• 1003-29-8 2-pyrrole aldehyde 

Relevant articles and documents

An unnatural hydrophobic base, 4-propynylpyrrole-2-carbaldehyde, as an efficient pairing partner of 9-methylimidazo[(4,5)-b]pyridine

To develop unnatural base pairs that function in replication, we designed 4-propynylpyrrole-2-carbaldehyde (designated as Pa′) and synthesized the nucleoside derivatives of Pa′. The base pairing of Pa′ with the partner, 9-methylimidazo[(4,5)-b]pyridine (Q), was compared to that of pyrrole-2-carbaldehyde (Pa), which was previously developed as a specific pairing partner of Q. The thermal stability of a DNA duplex containing the Q-Pa′ pair and the incorporation efficiency of the Pa′ substrate (dPa′TP) into DNA opposite Q by the Klenow fragment of Escherichia coli DNA polymerase I were improved, in comparison with those of the Q-Pa pair. These improvements result from the increased hydrophobicity and stacking stability of Pa′ by the introduction of the propynyl group to Pa, providing valuable information for the further development of unnatural base pairs toward the expansion of the genetic alphabet.