335592-59-1

Basic information

• Product Name: 4-[4-(1-tert-butoxycarbonylamino-1-methylethyl)phenyl]-2,5-dichloropyrimidine
• Synonyms: 4-[4-(1-tert-butoxycarbonylamino-1-methylethyl)phenyl]-2,5-dichloropyrimidine
• CAS NO: 335592-59-1
• Molecular Weight: 382.29
• Mol File: 335592-59-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-[4-(1-tert-butoxycarbonylamino-1-methylethyl)phenyl]-2,5-dichloropyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-(1-tert-butoxycarbonylamino-1-methylethyl)phenyl]-2,5-dichloropyrimidine(335592-59-1)
• EPA Substance Registry System: 4-[4-(1-tert-butoxycarbonylamino-1-methylethyl)phenyl]-2,5-dichloropyrimidine(335592-59-1)

Safety Data

• Hazardous Substances Data: 335592-59-1(Hazardous Substances Data)

Upstream product

• 17797-12-5 1-(4-bromophenyl)-1-methylethylamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 214973-83-8 tert-butyl (2-(4-bromophenyl)propan-2-yl)carbamate 
• 335592-60-4 tert-butyl (2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-propan-2-yl)carbamate 
• 5750-76-5 2,4,5-trichloropyrimidine 

Downstream Products

• 335592-43-3 4-[4-(1-tertbutoxycarbonylamino-1-methylethyl)phenyl]-5-chloro-N-[4-(2-hydroxyethyl)phenyl]pyrimidine-2-amine 
• 937366-50-2 C₂₄H₂₆BrClN₄O₂ 

Relevant articles and documents

Synthesis and biological study of 2-amino-4-aryl-5-chloropyrimidine analogues as inhibitors of VEGFR-2 and cyclin dependent kinase 1 (CDK1)

The series of 2-amino-4-aryl-5-chloropyrimidines was discovered to be potent for both VEGFR-2 and CDK1. Described here are the chemistry for analogue synthesis, SAR study, and its kinase selectivity prolifing. The full rat PK data and in vivo efficacy stu