937366-50-2

Basic information

• Product Name: C₂₄H₂₆BrClN₄O₂
• CAS NO: 937366-50-2
• Molecular Weight: 517.853
• Mol File: 937366-50-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₄H₂₆BrClN₄O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₂₆BrClN₄O₂(937366-50-2)
• EPA Substance Registry System: C₂₄H₂₆BrClN₄O₂(937366-50-2)

Safety Data

• Hazardous Substances Data: 937366-50-2(Hazardous Substances Data)

Upstream product

• 335592-59-1 4-[4-(1-tert-butoxycarbonylamino-1-methylethyl)phenyl]-2,5-dichloropyrimidine 
• 591-19-5 m-Bromoaniline 
• 17797-12-5 1-(4-bromophenyl)-1-methylethylamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 335592-60-4 tert-butyl (2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-propan-2-yl)carbamate 
• 214973-83-8 tert-butyl (2-(4-bromophenyl)propan-2-yl)carbamate 

Relevant articles and documents

Synthesis and biological study of 2-amino-4-aryl-5-chloropyrimidine analogues as inhibitors of VEGFR-2 and cyclin dependent kinase 1 (CDK1)

The series of 2-amino-4-aryl-5-chloropyrimidines was discovered to be potent for both VEGFR-2 and CDK1. Described here are the chemistry for analogue synthesis, SAR study, and its kinase selectivity prolifing. The full rat PK data and in vivo efficacy stu