341-39-9

Basic information

• Product Name: 2'-METHYL-2,2,2-TRIFLUOROACETOPHENONE
• Synonyms: 2'-METHYL-2,2,2-TRIFLUOROACETOPHENONE;2,2,2-trifluoro-1-o-tolylethanone
• CAS NO: 341-39-9
• Molecular Formula: C₉H₇F₃O
• Molecular Weight: 188.15
• Mol File: 341-39-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 188.6°C at 760 mmHg
• Flash Point: 76°C
• Appearance: /
• Density: 1.224g/cm³
• Vapor Pressure: 0.595mmHg at 25°C
• Refractive Index: 1.453
• CAS DataBase Reference: 2'-METHYL-2,2,2-TRIFLUOROACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-METHYL-2,2,2-TRIFLUOROACETOPHENONE(341-39-9)
• EPA Substance Registry System: 2'-METHYL-2,2,2-TRIFLUOROACETOPHENONE(341-39-9)

Safety Data

• Hazardous Substances Data: 341-39-9(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthetic Communications, 15, p. 1291, 1985 DOI: 10.1080/00397918508077277

InChI:InChI=1/C9H7F3O/c1-6-4-2-3-5-7(6)8(13)9(10,11)12/h2-5H,1H3

Upstream product

• 932-31-0 ortho-tolylmagnesium bromide 
• 76-05-1 trifluoroacetic acid 
• 383-63-1 ethyl trifluoroacetate, 
• 95-46-5 2-methylphenyl bromide 
• 104863-67-4 N-methoxy-N-methyltrifluoroacetamide 
• 353-85-5 trifluoroacetonitrile 
• 354-32-5 trifluoracetyl chloride 
• 438-24-4 2,2,2-trifluoro-1-(2'-methylphenyl)ethanol 
• 529-20-4 2-methylphenyl aldehyde 
• 108-88-3 toluene 
• 615-37-2 ortho-methylphenyl iodide 
• 201230-82-2 carbon monoxide 
• 89-71-4 2-Methyl-benzoic acid methyl ester 
• 81290-20-2 (trifluoromethyl)trimethylsilane 

Downstream Products

• 438-24-4 2,2,2-trifluoro-1-(2'-methylphenyl)ethanol 
• 80663-47-4 α-(trifluoromethyl)-2-methylstilbene 
• 131832-01-4 (R)-2,2,2-trifluoro-1-(2'-methylphenyl)ethanol 
• 438-24-4 (S)-2,2,2-trifluoro-1-(2'-methylphenyl)ethanol 
• 158884-40-3 1-Methyl-2-(2,2,2-trifluoroethyl)benzene 
• 158884-42-5 2-(2,2,2-Trifluoroethyl)benzaldehyde 
• 158884-41-4 1-(Bromomethyl)-2-(2,2,2-trifluoroethyl)benzene 
• 158884-11-8 <2-(2,2,2-Trifluoroethyl)phenyl>diazomethane 
• 158884-12-9 C₉H₆⁽²⁾HF₃N₂ 
• 158884-39-0 2,2,2-trifluoro-1-[2-(methyl)phenyl]ethyl 4-methylbenzenesulfonate 
• 158884-43-6 2-(2,2,2-Trifluoroethyl)benzaldehyde tosylhydrazone 
• 131832-04-7 (S)-Methoxy-phenyl-acetic acid (R)-2,2,2-trifluoro-1-o-tolyl-ethyl ester 
• 131832-04-7 (S)-Methoxy-phenyl-acetic acid (S)-2,2,2-trifluoro-1-o-tolyl-ethyl ester 
• 1682-47-9 2,2,2-Trifluor-1-o-tolyl-1-(4-chlor-phenyl)-aethan 

Relevant articles and documents

Palladium-catalyzed carbonylative coupling of aryl iodides with an organocopper reagent: A straightforward procedure for the synthesis of aryl trifluoromethyl ketones

A palladium-catalyzed carbonylative coupling of aryl iodides with a (trifluoromethyl)copper reagent has been developed. A wide range of substrates have been transformed into their corresponding trifluoromethyl ketones in good to excellent yields under mild conditions with high efficiency and excellent functional-group compatibility. Preliminary mechanistic investigations suggest that the transmetallation of an acylpalladium intermediate with the (trifluoromethyl)copper reagent seems to be involved in the catalytic cycle. Notably, this report represents one of the few studies on carbonylative coupling with organocopper reagents.

Synthesis of Perfluoroalkyl-Substituted Vinylcyclopropanes by Way of Enhanced Neighboring Group Participation

A simple, high yielding, two-step, one-pot protocol for the preparation of trifluoromethyl-substituted vinylcyclopropanes from α-CF3 homoallyl alcohols is disclosed. Destabilization of the cationic intermediate by the electron-withdrawing CF3 group greatly enhances neighboring group participation of the alkene, allowing ring closure to predominate. The reaction can be extended to the difluoromethyl and pentafluoroethyl group, enabling the preparation of a diverse array of fluoroalkyl-substituted vinylcyclopropanes. A diverse array of fluoroalkyl-substituted vinylcyclopropanes are prepared in a simple, high-yielding, two-step, one-pot protocol by means of cationic ring-closure.