438-24-4

Basic information

• Product Name: Benzenemethanol, 2-methyl-a-(trifluoromethyl)-
• CAS NO: 438-24-4
• Molecular Formula: C9H9F3O
• Molecular Weight: 190.165
• Mol File: 438-24-4.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 2-methyl-a-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 2-methyl-a-(trifluoromethyl)-(438-24-4)
• EPA Substance Registry System: Benzenemethanol, 2-methyl-a-(trifluoromethyl)-(438-24-4)

Safety Data

• Hazardous Substances Data: 438-24-4(Hazardous Substances Data)

Upstream product

• 75-63-8 Bromotrifluoromethane 
• 529-20-4 2-methylphenyl aldehyde 
• 75-46-7 trifluoromethan 
• 97-72-3 2-Methylpropionic anhydride 
• 95-46-5 2-methylphenyl bromide 
• 341-39-9 2-methyl-α,α,α-trifluoroacetophenone 
• 615-37-2 ortho-methylphenyl iodide 
• 407-38-5 2,2,2-trifluoroethyl trifluoroacetate 
• 421-53-4 2,2,2-trifluoro-1,1-ethanediol 
• 932-31-0 ortho-tolylmagnesium bromide 
• 2923-18-4 sodium 2,2,2-trifluoroacetate 
• 81290-20-2 (trifluoromethyl)trimethylsilane 

Downstream Products

• 158884-39-0 2,2,2-trifluoro-1-[2-(methyl)phenyl]ethyl 4-methylbenzenesulfonate 
• 1135312-19-4 2,2,2-trifluoro-1-(2'-methylphenyl)ethyl isobutyrate 
• 1135311-82-8 (S)-2,2,2-trifluoro-1-(2'-methylphenyl)ethyl isobutyrate 
• 131832-01-4 (R)-2,2,2-trifluoro-1-(2'-methylphenyl)ethanol 
• 438-24-4 (S)-2,2,2-trifluoro-1-(2'-methylphenyl)ethanol 
• 341-39-9 2-methyl-α,α,α-trifluoroacetophenone 
• 158884-43-6 2-(2,2,2-Trifluoroethyl)benzaldehyde tosylhydrazone 
• 158884-12-9 C₉H₆⁽²⁾HF₃N₂ 

Relevant articles and documents

Synthesis of Unsymmetric Triarylmethanes Bearing CF 3-Substituted All-Carbon Quaternary Stereocenters: 1,6-Arylation of δ-Trifluo romethyl Substituted para -Quinone Methides

Pre-synthesized δ-CF 3-δ-aryl-disubstituted para -quinone methides bearing δ-substituents were identified as isolable and storable substrates for 1,6-arylation reactions. A broad range of electron-rich arenes and heteroarenes participated in the arylation process, furnishing a wide array of unsymmetrical CF 3-substituted triarylmethanes in high efficiency. The mild and expeditious protocol exhibited broad scopes of both arene and para -quinone methide components.

Gas/Liquid-Phase Micro-Flow Trifluoromethylation using Fluoroform: Trifluoromethylation of Aldehydes, Ketones, Chalcones, and N-Sulfinylimines

A micro-flow nucleophilic trifluoromethylation of carbonyl compounds using gaseous fluoroform was developed. This method also allows the first micro-flow transformation of N-sulfinylimines into trifluoromethyl amines with excellent diastereoselectivity. To demonstrate the synthetic utility of this micro-flow synthesis, the formal micro-flow synthesis of Efavirenz is described.

Catalytic highly enantioselective transfer hydrogenation of β-trifluoromethyl nitroalkenes. An easy and general entry to optically active β-trifluoromethyl amines

In the presence of a thiourea catalyst, β-CF3 nitroalkenes react with Hantzsch esters in a highly enantioselective fashion, giving a broad range of β-CF3 amine precursors with a tertiary stereocentre at the β-position. This reaction