343-65-7 Usage
Description
DL-Kynurenine, also known as a tryptophan metabolite, is an amino acid produced in the body from tryptophan. It is a ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group. DL-Kynurenine serves as a precursor to kynurenic acid, which acts as an antagonist of the N-methyl-aspartate receptor.
Uses
Used in Pharmaceutical Industry:
DL-Kynurenine is used as a vasodilator and immunomodulator for its ability to regulate blood flow and modulate the immune system.
Used in Neuropharmacology:
DL-Kynurenine is used as a precursor for the synthesis of kynurenic acid, which is an antagonist of the N-methyl-aspartate (NMDA) receptor. This application is crucial in the study and treatment of various neurological disorders and conditions related to the NMDA receptor.
Used in Research and Development:
As a tryptophan metabolite, DL-Kynurenine is utilized in research and development for understanding the metabolic pathways of tryptophan and its role in various physiological processes and diseases.
Purification Methods
Crystallise it from H2O or aqueous AcOH. The picrate has m 188.5-189o(dec) after crystallisation from H2O. (±)-Kynurenine has m 218o. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p2726 1961, Beilstein 14 III 1657, 14 IV 2562.]
Check Digit Verification of cas no
The CAS Registry Mumber 343-65-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,4 and 3 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 343-65:
(5*3)+(4*4)+(3*3)+(2*6)+(1*5)=57
57 % 10 = 7
So 343-65-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)
343-65-7Relevant articles and documents
Products arising in the performic oxidation of tryptophan.
Benassi,Scoffone,Veronese
, p. 4389 - 4393 (1965)
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Composition for Topical Use
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, (2010/12/31)
The use, as a dermatological or cosmetic medicament, of compounds capable of transiently interacting with the AhR receptor (aryl hydrocarbon receptor) as agents for modulating skin functions such as sebaceous function, skin healing, skin atrophy termed “dermatoporosis”, estrogen deprivation and defense against infection, without inducing other toxic effects of the TCDD type. The compounds that interact with the AhR receptor are chosen in that they have a metabolism favorable to the dissociation of these effects, in particular by virtue of in situ production from a precursor and/or metabolization modulated in situ.
Oxidative transformation of tryptophan to 3-(2-aminophenyl)-2-pyrrolidone and kynurenine
Nakagawa,Kato,Fukazawa,et al.
, p. 5871 - 5874 (2007/10/02)
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