34352-59-5

Basic information

• Product Name: 1-METHYLPIPERAZINE DIHYDROCHLORIDE
• Synonyms: 1-Methylpiperazine2HCl;1-METHYLPIPERAZINE DIHYDROCHLORIDE 98%;1-Methylpiperazine dihydrochloride,98%;N-Methyl piperazine hydrochloride;1-METHYLPIPERAZINE D;TIMTEC-BB SBB003822;1-METHYLPIPERAZINE DIHYDROCHLORIDE
• CAS NO: 34352-59-5
• Molecular Formula: C₅H₁₄N₂*2Cl
• Molecular Weight: 173.08
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Piperazines;Building Blocks;C4 to C8;Chemical Synthesis;Heterocyclic Building Blocks
• Mol File: 34352-59-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 246-250 °C(lit.)
• Boiling Point: 138 °C at 760 mmHg
• Flash Point: 42.2 °C
• Appearance: White to off-white/Powder
• Vapor Pressure: 6.86mmHg at 25°C
• Storage Temp.: Refrigerator
• Solubility: 1 M NH4OH: soluble25mg/mL, clear to hazy, colorless to light yel
• CAS DataBase Reference: 1-METHYLPIPERAZINE DIHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYLPIPERAZINE DIHYDROCHLORIDE(34352-59-5)
• EPA Substance Registry System: 1-METHYLPIPERAZINE DIHYDROCHLORIDE(34352-59-5)

Safety Data

• Hazard Codes: T
• Statements: 23/24/25-36/37/38
• Safety Statements: 26-28-36/37/39-45
• WGK Germany: 3
• Hazardous Substances Data: 34352-59-5(Hazardous Substances Data)

Usage

Description

1-METHYLPIPERAZINE DIHYDROCHLORIDE, also known as Methylpiperazine dihydrochloride, is an off-white to light yellow powder with significant chemical properties. It is a compound that plays a crucial role in the synthesis of various pharmaceuticals and has applications across different industries.

Uses

Used in Pharmaceutical Industry:
1-METHYLPIPERAZINE DIHYDROCHLORIDE is used as a chemical intermediate for the synthesis of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone (MPMAP), an antimicrotubular drug. This application is due to its ability to contribute to the development of effective treatments for various medical conditions.
Used in Chemical Synthesis:
1-METHYLPIPERAZINE DIHYDROCHLORIDE is used as a reagent in the preparation of 1-methylpiperazine-1,4-diium tetrachloridozincate hemihydrate. This application highlights its versatility in chemical reactions and its importance in creating new compounds with potential applications in various fields.

InChI:InChI=1/C5H12N2.2ClH/c1-7-4-2-6-3-5-7;;/h6H,2-5H2,1H3;2*1H

Upstream product

• 2055-46-1 3,4,5,6-tetrahydropyrimidine-2-thione 
• 42951-91-7 2-chloro-1-(4-methylpiperazin-1-yl)ethan-1-one hydrochloride 
• 93378-52-0 1-methyl-4-(2-tetrahydropyrimidinylthioacetyl)piperazine dihydrochloride 
• 93378-54-2 1-methyl-4-(2-tetrahydro-1,3-diazepinylthioacetyl)piperazine dihydrochloride 
• 109-01-3 1-methyl-piperazine 
• 7647-01-0 hydrogenchloride 
• 5625-52-5 1-methylpiperazin-2,5-dione 
• 62226-74-8 1-benzyl-4-methylpiperazine 

Downstream Products

• 60868-01-1 3-(4-methylpiperazin-1-yl)-1-phenylpropan-1-one 
• 100316-89-0 3-(4-methyl-piperazino)-1-[2]thienyl-propan-1-one 
• 102166-95-0 1-(2-benzhydryloxy-ethyl)-4-methyl-piperazine 
• 132502-06-8 1-[2-(2-benzyl-phenoxy)-ethyl]-4-methyl-piperazine 
• 33860-28-5 4-methylpiperazine-1-carbothioamide 
• 28920-67-4 1-(2-ethoxy-2-oxoethyl)-4-methylpiperazine 
• 18413-26-8 4-methylpiperazin-1-yl-biguanidine dihydrochloride 
• 60868-03-3 1-(4-methoxy-phenyl)-3-(4-methyl-piperazin-1-yl)-propan-1-one 
• 83808-21-3 2-(4-methyl-1-piperazinyl)acetamide 
• 74976-33-3 3-(4-methyl-1-piperazinylmethyl)-6-chloro-5-azaindole 
• 75956-17-1 2-Methyl-6-[2-(4-methyl-piperazin-1-yl)-ethyl]-4-o-tolyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 75956-13-7 4-(2-Chloro-phenyl)-2-methyl-6-[2-(4-methyl-piperazin-1-yl)-ethyl]-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 75956-05-7 2-Methyl-6-[2-(4-methyl-piperazin-1-yl)-ethyl]-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 75956-02-4 2-Methyl-6-[2-(4-methyl-piperazin-1-yl)-ethyl]-4-(2-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester 

Relevant articles and documents

Highly chemoselective Pd-C catalytic hydrodechlorination leading to the highly efficient N-debenzylation of benzylamines

(Equation Presented) In the presence of 1,1,2-trichloroethane, a novel procedure for the Pd-C catalytic N-debenzylation of benzylamines was established. The method proceeded in a synergistic catalytic system and directly gave the products as crystal amine hydrochlorides in practically quantitative yields.

Modular syntheses of multidentate ligands with variable N-donors: Applications to tri- and tetracopper(i) complexes

A general method for the preparation of multidentate ligands comprised of a multi-imine platform derived from 1,1,1-tris(aminomethyl)ethane or tris(aminoethyl)amine connected to bi- and tridentate N-donor chelates has been developed. The feasibility of the method has been demonstrated through the synthesis and characterization of a large set of these ligand types. Complexation to Cu(i) was accomplished for several cases, yielding tri- and tetracopper(i) complexes that have been characterized in solution by NMR spectroscopy and conductivity, and in the solid state by elemental analysis, mass spectrometry, and/or X-ray crystallography. These complexes are potentially useful for modeling multicopper protein active sites. The Royal Society of Chemistry.

Isotopically enriched N-substituted piperazines and methods for the preparation thereof

In some embodiments, this invention pertains to isotopically enriched N-substituted piperazines. In some embodiments, this invention pertains to methods for the preparation of isotopically enriched N-substituted piperazines.