348-45-8

Basic information

• Product Name: BENZOTHIAZOL-2-YL-(4-FLUORO-PHENYL)-AMINE
• Synonyms: N-(4-fluorophenyl)-1,3-benzothiazol-2-amine
• CAS NO: 348-45-8
• Molecular Formula: C₁₃H₉FN₂S
• Molecular Weight: 244.29
• Mol File: 348-45-8.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 372.2 °C at 760 mmHg
• Flash Point: 178.9 °C
• Appearance: /
• Density: 1.384 g/cm³
• Vapor Pressure: 9.75E-06mmHg at 25°C
• Refractive Index: 1.723
• CAS DataBase Reference: BENZOTHIAZOL-2-YL-(4-FLUORO-PHENYL)-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: BENZOTHIAZOL-2-YL-(4-FLUORO-PHENYL)-AMINE(348-45-8)
• EPA Substance Registry System: BENZOTHIAZOL-2-YL-(4-FLUORO-PHENYL)-AMINE(348-45-8)

Safety Data

• Hazardous Substances Data: 348-45-8(Hazardous Substances Data)

Usage

General Description

Benzothiazol-2-yl-(4-fluoro-phenyl)-amine is a chemical compound that belongs to the class of benzothiazole compounds. It is a derivative of 4-fluorophenylamine and contains a benzothiazole ring system. BENZOTHIAZOL-2-YL-(4-FLUORO-PHENYL)-AMINE has potential applications in pharmaceutical and agrochemical industries due to its structural features and potential biological activities. It can be used as a building block in the synthesis of various pharmaceutical and agrochemical compounds. Additionally, it may also have potential applications in material science and organic synthesis. The compound's specific properties and potential applications would need to be further investigated and studied.

InChI:InChI=1/C13H9FN2S/c14-9-5-7-10(8-6-9)15-13-16-11-3-1-2-4-12(11)17-13/h1-8H,(H,15,16)

Upstream product

• 615-20-3 2-chlorobenzo[d][1,3]thiazole 
• 371-40-4 4-fluoroaniline 
• 370-16-1 N-(4-fluorophenyl)-N’-phenylthiourea 
• 103-72-0 phenyl isothiocyanate 
• 615-43-0 2-iodophenylamine 
• 1544-68-9 4-fluorophenyl isothiocyanate 
• 137-07-5 2-amino-benzenethiol 
• 2740-81-0 2-chlorophenylisothiocyanate 
• 368-07-0 N-(2-chloro-phenyl)-N'-(4-fluoro-phenyl)-thiourea 
• 88-74-4 2-nitro-aniline 
• 33692-68-1 N-(4-fluorophenyl)methyl dithiocarbamic acid 
• 75-15-0 carbon disulfide 

Relevant articles and documents

Environment-friendly and efficient synthesis of 2-aminobenzo-xazoles and 2-aminobenzothiazoles catalyzed by: Vitreoscilla hemoglobin incorporating a cobalt porphyrin cofactor

In this study, an environment-friendly and efficient artificial Vitreoscilla hemoglobin (VHb) for the synthesis of 2-aminobenzoxazoles and 2-aminobenzothiazoles has been reported. We demonstrate an expression-based porphyrin substitution strategy to produce VHb containing cobalt porphyrin instead of native hemin, which can catalyze the oxidative cyclization of corresponding 2-aminobenzoxazoles and 2-aminobenthiazoles with up to 97% yield and 4850 catalytic turnovers in water under aerobic conditions. Hence, we provide a green and mild method for the synthesis of 2-aminobenzoxazoles and 2-aminobenzothiazoles. In addition, we indicate the value of porphyrin ligand substitution as a strategy to tune and enhance the catalytic properties of hemoproteins in non-natural reactions.

A practical synthesis of 2-aminobenzothiazoles via copper(I)-catalyzed tandem reaction of 2-iodoanilines with isothiocyanates in ionic liquids

A copper(I)-catalyzed tandem reaction of 2-iodoanilines with isothiocyanates was achieved in hydrophobic [bmim][PF6] ionic liquid under mild conditions, generating a variety of 2-aminobenzothiazoles in good to excellent yields. The tandem reaction that was carried out in [bmim][PF6] has some obvious advantages such as accelerated reaction rate and increased yield as compared with the reaction run in volatile solvents such as toluene. Furthermore, the CuI/1,10-phenanthroline catalytic system can be reused up to eight times without loss of activity and efficiency.

Straightforward synthesis of 2-anilinobenzoxazoles and -benzothiazoles via mechanochemical ball-milling-promoted one-pot reactions

Under mechanochemical ball-milling and solvent-free conditions, a series of 2-anilinobenzoxazoles and -thiazoles were synthesized directly from the one-pot reaction of anilines, CS2, and 2-aminophenol and -thiophenol. This protocol exhibits the