370-16-1

Basic information

• Product Name: 1-(4-fluorophenyl)-3-phenylthiourea
• Synonyms: 1-(4-Fluorophenyl)-3-phenylthiourea; N-(4-fluorophenyl)-N'-phenylthiourea; thiourea, N-(4-fluorophenyl)-N'-phenyl-
• CAS NO: 370-16-1
• Molecular Formula: C₁₃H₁₁FN₂S
• Molecular Weight: 246.3032
• Mol File: 370-16-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 347.2°C at 760 mmHg
• Flash Point: 163.8°C
• Density: 1.353g/cm³
• Vapor Pressure: 5.47E-05mmHg at 25°C
• Refractive Index: 1.726
• CAS DataBase Reference: 1-(4-fluorophenyl)-3-phenylthiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-fluorophenyl)-3-phenylthiourea(370-16-1)
• EPA Substance Registry System: 1-(4-fluorophenyl)-3-phenylthiourea(370-16-1)

Safety Data

• Hazardous Substances Data: 370-16-1(Hazardous Substances Data)

Usage

General Description

1-(4-fluorophenyl)-3-phenylthiourea is a chemical compound with the molecular formula C13H10FN3S. It is a derivative of thiourea and contains a fluorine-substituted phenyl group and a phenyl group attached to the nitrogen atom. 1-(4-fluorophenyl)-3-phenylthiourea has been studied for its potential applications in pharmaceutical research, particularly in the development of new drugs and treatments. It may also have uses in other fields such as organic synthesis and materials science. The exact properties and potential uses of 1-(4-fluorophenyl)-3-phenylthiourea continue to be the subject of ongoing research and investigation.

Upstream product

• 62-53-3 aniline 
• 1544-68-9 4-fluorophenyl isothiocyanate 
• 404-52-4 N,N’-di-(4-fluorophenyl)thiourea 
• 371-40-4 4-fluoroaniline 
• 75-15-0 carbon disulfide 
• 24075-34-1 4-fluorophenyl isocyanide 
• 459-25-6 N-(4-fluorophenyl)formamide 

Downstream Products

• 348-45-8 N-(4-fluorophenyl)benzo[d]thiazol-2-amine 

Relevant articles and documents

Hydroamination and Hydrophosphination of Isocyanates/Isothiocyanates under Catalyst-Free Conditions

Symmetrical and unsymmetrical N,N’-disubstituted as well as trisubstituted ureas/thioureas by the hydroamination of isocyanates/isothiocyanates, and various phosphathioureas by the hydrophosphination of isothiocyanates have been synthesized in good to excellent yields under catalyst-free and mild conditions. This protocol is also applicable for the efficient synthesis of chiral ureas and thioureas and common herbicides, such as fenuron and monuron.

Nickle Catalysis Enables Access to Thiazolidines from Thioureas via Oxidative Double Isocyanide Insertion Reactions

An efficient synthesis of thiazolidine-2,4,5-triimine derivatives was developed via Ni-catalyzed oxidative double isocyanide insertion to thioureas under air conditions, in which thioureas play three roles as a substrate, a ligand, and overcoming isocyanide polymerization. The reaction is featured by employing a low-cost and low loading Ni(acac)2 catalyst, without any additives, and high atom economy. This is the first example to directly apply a Ni(II) catalyst in oxidative double isocyanide insertion reactions.

Convenient synthesis of unsymmetrical N,N′-disubstituted thioureas in water

A simple and convenient two-step method has been developed and used to synthesise 25 (4 of which are novel) unsymmetrical N,N′-disubstituted thioureas in water. Alkylamines or variously substituted arylamines reacted smoothly with phenyl chlorothionoformate at room temperature to form thiocarbamates, which were then reacted with another alkyl- or arylamine in water at reflux to afford the unsymmetrical N,N′-disubstituted thioureas in good to excellent yields. Mild conditions, simple work-up, high yields as well as using water as solvent are the major advantages of the method.