351-64-4

Basic information

• Product Name: Propanoic acid, 2-(4-fluorophenylhydrazono)-, ethyl ester
• Synonyms: Propanoic acid, 2-(4-fluorophenylhydrazono)-, ethyl ester
• CAS NO: 351-64-4
• Molecular Formula: C₁₁H₁₃FN₂O₂
• Molecular Weight: 224.23
• Mol File: 351-64-4.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Propanoic acid, 2-(4-fluorophenylhydrazono)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 2-(4-fluorophenylhydrazono)-, ethyl ester(351-64-4)
• EPA Substance Registry System: Propanoic acid, 2-(4-fluorophenylhydrazono)-, ethyl ester(351-64-4)

Safety Data

• Hazardous Substances Data: 351-64-4(Hazardous Substances Data)

Upstream product

• 609-14-3 2-acetylpropanoic acid ethyl ester 
• 20893-71-4 4-fluorophenyldiazonium chloride 
• 617-35-6 2-oxo-propionic acid ethyl ester 
• 371-14-2 4-fluorophenylhydrazine 
• 459-45-0 4-fluorobenzenediazonium tetrafluoroborate 
• 371-40-4 4-fluoroaniline 
• 61161-10-2 N-(4-fluorophenyl)-nitramine 
• 823-85-8 4-fluorophenyhydrazine hydrochloride 

Downstream Products

• 348-36-7 ethyl 5-fluoro-1H-indole-2-carboxylate 
• 399-52-0 5-fluoro-1H-indole 
• 399-76-8 5-fluoroindole-2-carboxylic acid 
• 343-90-8 3-dimethylaminomethyl-5-fluoroindole 
• 1159691-42-5 ethyl 1-(4-fluorophenyl)-4-formyl-1H-pyrazole-3-carboxylate 
• 1488427-01-5 N-{{5-fluoro-2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indol-3-yl}methyl}-3,4,5-trimethoxybenzenamine 
• 1488427-07-1 N-{{5-fluoro-2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indol-3-yl}methyl}-2-morpholinoethan-1-amine 
• 1488427-11-7 N-{{5-fluoro-2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indol-3-yl}methyl}-2-(pyrrolidin-1-yl)ethan-1-amine 
• 1488427-13-9 N-{{5-fluoro-2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indol-3-yl}methyl}-2-methoxyethan-1-amine 
• 1488427-15-1 N-{{5-fluoro-2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indol-3-yl}methyl}(4-methoxyphenyl)methanamine 
• 1488427-17-3 N-{{5-fluoro-2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indol-3-yl}methyl}(3-methoxyphenyl)methanamine 
• 1488427-20-8 5-fluoro-2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-3-(morpholinomethyl)-1H-indole 
• 1488427-25-3 5-fluoro-2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-3-[(3-methylpiperidin-1-yl)methyl]-1H-indole 

Relevant articles and documents

Synthesis of Azepino[1,2-a]indole-10-amines via [6+1] Annulation of Ynenitriles with Reformatsky Reagent

Lewis acid-catalyzed [6+1] annulation reactions of 2-cyano-1-propargyl- and 2-alkynyl-1-cyanomethyl-indoles with Reformatsky reagent are described. 8-Aryl, 8-alkyl-, 8-hetaryl-, 9-aryl, and 9-alkyl-azepino[1,2-a]indole amines were obtained through a 7-endo-mode cyclization of the β-aminoacrylate intermediates. The antiproliferative activity of the azepino[1,2-a]indoles analogs against the HCT-116 cells were also examined.

Rh(II)-catalyzed intramolecular annulation of N-sulfonyl 1,2,3-triazoles with indole derivatives: A new method for synthesis pyranoindoles

A direct and highly stereoselective approach for the synthesis of Z-alkenyl-pyranoindoles had been developed by utilizing Rh(II)-catalyzed intramolecular cyclization of N-sulfonyl-1,2,3-triazoles with indole derivatives. A variety of pyranoindoles were obtained in 44-93% yields. Moreover, a more convenient synthesis of pyranoindoles starting from terminal alkyne was realized via a Cu-Rh sequentially catalyzed one-pot cascade reaction.

Indole-3-carbinol and 1,3,4-oxadiazole hybrids: Synthesis and study of anti-proliferative and anti-microbial activity

In the present study, molecular hybrids of indole-3-carbinol and 1,3,4-oxadiazole-2-thiols have been designed and synthesized. The thiol analogues consisted of diversely substituted benzyl and alkyl groups with different electronic properties. The structures of all the newly synthesized scaffolds and target compounds were ascertained using 1H NMR, 13C NMR, mass spectrometry, and elemental analyses. All the final compounds were screened in vitro for their anti-proliferative and anti-microbial activity. Three compounds showed excellent anti-proliferative activity with more than 70% cell growth inhibition against three cancer cell lines, HepG2 (human liver hepatocellular carcinoma), HeLa (human cervix carcinoma), and MCF-7 (human breast carcinoma). In the anti-microbial studies, compounds with electron-withdrawing fluoro or nitro substituent displayed appreciable activity similar to that of standard drugs. Also, the final compounds are non-toxic to non-cancerous Vero cell line.