348-36-7 Usage
Description
ETHYL 5-FLUOROINDOLE-2-CARBOXYLATE is a light yellow powder that serves as a versatile reactant in the pharmaceutical and chemical industries. It is utilized in the preparation of various therapeutic agents, including antitumor, antihyperlipidemic, and antiarrhythmic compounds, as well as inhibitors of factor Xa, cytosolic phospholipase A2, and thromboxane receptor antagonist and synthase.
Uses
Used in Pharmaceutical Industry:
ETHYL 5-FLUOROINDOLE-2-CARBOXYLATE is used as a reactant for the preparation of antitumor agents for their potential in combating cancer cells and tumor growth.
ETHYL 5-FLUOROINDOLE-2-CARBOXYLATE is used as a reactant for the preparation of antihyperlipidemic agents to help regulate lipid levels in the body and prevent related health issues.
ETHYL 5-FLUOROINDOLE-2-CARBOXYLATE is used as a reactant for the preparation of factor Xa inhibitors, which play a role in the coagulation process and can be useful in treating conditions related to blood clotting.
ETHYL 5-FLUOROINDOLE-2-CARBOXYLATE is used as a reactant for the preparation of potential antiarrhythmic agents, which can help regulate heart rhythm and prevent abnormal heart beats.
ETHYL 5-FLUOROINDOLE-2-CARBOXYLATE is used as a reactant for the preparation of inhibitors of the cytosolic phospholipase A2, which are involved in various inflammatory processes and pain perception.
ETHYL 5-FLUOROINDOLE-2-CARBOXYLATE is used as a reactant for the preparation of thromboxane receptor antagonist and thromboxane synthase inhibitor via Mitsunobu reaction, which can have implications in treating cardiovascular diseases and conditions related to blood clotting.
Check Digit Verification of cas no
The CAS Registry Mumber 348-36-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,4 and 8 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 348-36:
(5*3)+(4*4)+(3*8)+(2*3)+(1*6)=67
67 % 10 = 7
So 348-36-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H10FNO2/c1-2-15-11(14)10-6-7-5-8(12)3-4-9(7)13-10/h3-6,13H,2H2,1H3
348-36-7Relevant articles and documents
INDOLE DERIVATIVES AND USES THEREOF FOR TREATING A CANCER
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Page/Page column 72; 82; 88; 151-152, (2022/02/06)
The present invention relates to indole derivatives of formula (I') as CK2 inhibitor and pharmaceutical compositions comprising the same. The present invention further relates to the use of such compounds of formula (I) for use for preventing and/or treating a cancer.
Scaffold Hopping of Natural Product Evodiamine: Discovery of a Novel Antitumor Scaffold with Excellent Potency against Colon Cancer
Wang, Lei,Fang, Kun,Cheng, Junfei,Li, Yu,Huang, Yahui,Chen, Shuqiang,Dong, Guoqiang,Wu, Shanchao,Sheng, Chunquan
, p. 696 - 713 (2020/02/04)
Inspired by the natural product evodiamine, a novel antitumor indolopyrazinoquinazolinone scaffold was designed by scaffold hopping. Structure-activity relationship studies led to the discovery of compound 15j, which shows low nanomolar inhibitory activity against the HCT116 cell line. Further antitumor mechanism studies indicated that compound 15j acted by the dual inhibition of topoisomerase 1 and tubulin and induced apoptosis with G2 cell-cycle arrest. The quaternary ammonium salt of compound 15j (compound 15js) exhibited excellent in vivo antitumor activity (TGI = 66.6%) in the HCT116 xenograft model with low toxicity. Indolopyrazinoquinazolinone derivatives represent promising multitargeting antitumor leads for the development of novel antitumor agents.
ANTIBACTERIAL COMPOUNDS
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Page/Page column 86-89; 101, (2019/11/04)
The present application provides compounds of formula: Methods of using these compounds for killing bacterial growth and treating bacterial infections are also provided.
