353497-35-5

Basic information

• Product Name: Benzeneacetic acid, 2-[(methoxycarbonyl)phenylamino]-
• CAS NO: 353497-35-5
• Molecular Formula: C16H15NO4
• Molecular Weight: 285.299
• Mol File: 353497-35-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzeneacetic acid, 2-[(methoxycarbonyl)phenylamino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, 2-[(methoxycarbonyl)phenylamino]-(353497-35-5)
• EPA Substance Registry System: Benzeneacetic acid, 2-[(methoxycarbonyl)phenylamino]-(353497-35-5)

Safety Data

• Hazardous Substances Data: 353497-35-5(Hazardous Substances Data)

Upstream product

• 3335-98-6 1-phenyl-1,3-dihydro-indol-2-one 
• 79-22-1 methyl chloroformate 
• 616-38-6 carbonic acid dimethyl ester 
• 805236-74-2 [2-(methoxycarbonyl-phenyl-amino)-phenyl]-acetic acid methyl ester 

Downstream Products

• 3335-98-6 1-phenyl-1,3-dihydro-indol-2-one 
• 353497-31-1 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxylic acid methyl ester 
• 731851-81-3 {2-[Phenyl-(2,2,2-trifluoro-acetyl)-amino]-phenyl}-acetic acid 
• 731851-78-8 [2-(benzyl-phenyl-amino)-phenyl]-acetic acid 
• 731851-92-6 (2-phenylamino-phenyl)-acetic acid benzyl ester 
• 731851-88-0 [2-(acetyl-phenyl-amino)-phenyl]-acetic acid 
• 39507-06-7 (2-phenylamino-phenyl)-acetic acid methyl ester 
• 70172-33-7 2-[2-(phenylamino)phenyl]acetic acid 
• 28721-09-7 10-methoxy-5H-dibenz[b,f]azepine-5-carboxamide 
• 4698-11-7 10-methoxy-5H-dibenzo[b,f]azepine 
• 21737-58-6 10,11-dihydro-5H-dibenzo[b,f]azepin-10-one 
• 28721-07-5 oxcarbazepine 

Relevant articles and documents

A new industrial process for oxcarbazepine

A novel industrial process for the antiepileptic drug oxcarbazepine 1 has been developed. Unlike the old process, the new process is free from halogenated solvents and can be performed in standard production equipment. It starts from commercially available 1,3-dihydro-1-phenyl-2H-indol-2-one 10. In the key step, an electrophilic ring closure reaction of 2-[(methoxycarbonyl)phenylamino] benzeneacetic acid 5 to 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxylic acid methyl ester 6 in poly phosphoric acid was applied. For the manufacture of 5, a highly efficient process using a dianion strategy was developed.

Dibenzo(b,f)azepine derivatives and their preparation

The invention relates to new processes for the preparation of the pharmaceutical oxcarbazepine, as well as novel intermediates prepared by or used for said processes, and the preparation of said intermediates.