805236-74-2

Basic information

• Product Name: Benzeneacetic acid, 2-[(methoxycarbonyl)phenylamino]-, methyl ester
• CAS NO: 805236-74-2
• Molecular Formula: C17H17NO4
• Molecular Weight: 299.326
• Mol File: 805236-74-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzeneacetic acid, 2-[(methoxycarbonyl)phenylamino]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, 2-[(methoxycarbonyl)phenylamino]-, methyl ester(805236-74-2)
• EPA Substance Registry System: Benzeneacetic acid, 2-[(methoxycarbonyl)phenylamino]-, methyl ester(805236-74-2)

Safety Data

• Hazardous Substances Data: 805236-74-2(Hazardous Substances Data)

Upstream product

• 3335-98-6 1-phenyl-1,3-dihydro-indol-2-one 
• 67-56-1 methanol 
• 75-44-5 phosgene 
• 39507-06-7 (2-phenylamino-phenyl)-acetic acid methyl ester 

Downstream Products

• 731851-81-3 {2-[Phenyl-(2,2,2-trifluoro-acetyl)-amino]-phenyl}-acetic acid 
• 353497-31-1 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxylic acid methyl ester 
• 39507-06-7 (2-phenylamino-phenyl)-acetic acid methyl ester 
• 70172-33-7 2-[2-(phenylamino)phenyl]acetic acid 
• 28721-09-7 10-methoxy-5H-dibenz[b,f]azepine-5-carboxamide 
• 4698-11-7 10-methoxy-5H-dibenzo[b,f]azepine 
• 21737-58-6 10,11-dihydro-5H-dibenzo[b,f]azepin-10-one 
• 3335-98-6 1-phenyl-1,3-dihydro-indol-2-one 
• 28721-07-5 oxcarbazepine 
• 353497-35-5 2-[(methoxycarbonyl)phenylamino]benzeneacetic acid 

Relevant articles and documents

A new industrial process for oxcarbazepine

A novel industrial process for the antiepileptic drug oxcarbazepine 1 has been developed. Unlike the old process, the new process is free from halogenated solvents and can be performed in standard production equipment. It starts from commercially available 1,3-dihydro-1-phenyl-2H-indol-2-one 10. In the key step, an electrophilic ring closure reaction of 2-[(methoxycarbonyl)phenylamino] benzeneacetic acid 5 to 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxylic acid methyl ester 6 in poly phosphoric acid was applied. For the manufacture of 5, a highly efficient process using a dianion strategy was developed.