35453-19-1Relevant articles and documents
Method for preparing 5 -amino -2, 4 and 6 -iodoisophthalate
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Paragraph 0038-0051, (2021/09/29)
The invention relates to a method for preparing 5 - amino -2, 4 and 6 - triiodoisophthalic acid, in particular to an iodine simple substance. The iodate is reacted with 5 - aminoisophthalic acid or a salt thereof in a mixed solution. The reaction product can be used in the synthesis X-ray imaging diagnosis technology intermediate of contrast medium. The preparation method is convenient and simple in process operation, excellent in yield, safe, environment-friendly and green, and can be used for large-scale industrial production.
Method for preparing 5-amino-2,4,6-triiodoisophthalic acid
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Paragraph 0050-0067, (2019/10/04)
The invention relates to a method for preparing iodized aniline. The method specifically comprises the steps that an iodized metal salt or hydrogen iodide is taken to react with iodoxylic acid or a salt thereof, and then subjected to an iodine reaction with the compound shown in the formula (I) in a polar solvent under acidic conditions, purification is conducted, and 5-amino-2,4,6-triiodophthalicacid as shown in the formula (II) is obtained. The 5-amino-2,4,6-triiodophthalic acid is an intermediate which can be used for synthesizing an iodic contrast medium widely applied to medical imaging.According to the preparation method, the raw materials are stable, the process is simple, and the yield is very high, large-scale industrial production can be achieved, and industrial application andpopularization are facilitated.
Synthesis and evaluation of potential CT (computer tomography) contrast agents for bone structure and microdamage analysis
Parkesh, Raman,Gowin, Wolfgang,Lee, T. Clive,Gunnlaugsson, Thorfinnur
, p. 3611 - 3617 (2008/09/19)
The design and synthesis of several novel X-ray contrast agents 1-3, developed for targeting bone structures, and in particularly microcracks in bones, using CT (Computer Tomography) detection is described. These contrast agents are based on the use of the well known triiodobenzene platform, which was conjugated into one or more phenyliminodiacetate moieties, which can be used to 'lock' onto bone matrices. Compounds 1-3 were all tested for their ability to visualise cracks in bone structures (bovine bones) using μ-CT imaging. The Royal Society of Chemistry 2006.