362-46-9

Basic information

• Product Name: 5-fluoro-2-aMinobenzophenone
• Synonyms: 5-fluoro-2-aMinobenzophenone;2-mino-5-fluorobenzophenone
• CAS NO: 362-46-9
• Molecular Formula: C₁₃H₁₀FNO
• Molecular Weight: 215.2230032
• Mol File: 362-46-9.mol
• Article Data: 17

Chemical Properties

• Melting Point: 118 °C
• Boiling Point: 396.9±32.0 °C(Predicted)
• Appearance: /
• Density: 1.236±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 0.75±0.10(Predicted)
• CAS DataBase Reference: 5-fluoro-2-aMinobenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-fluoro-2-aMinobenzophenone(362-46-9)
• EPA Substance Registry System: 5-fluoro-2-aMinobenzophenone(362-46-9)

Safety Data

• Hazardous Substances Data: 362-46-9(Hazardous Substances Data)

Usage

General Description

5-fluoro-2-aminobenzophenone is a chemical compound that belongs to the class of organic compounds known as benzophenones. It is a synthetic intermediate that is commonly used in organic synthesis and pharmaceutical research. This chemical is a fluorine-substituted derivative of 2-aminobenzophenone, which is a versatile building block in the synthesis of various pharmaceuticals and agrochemicals. The presence of the fluorine atom in 5-fluoro-2-aminobenzophenone can enhance its biological activity and improve its pharmacokinetic properties. 5-fluoro-2-aMinobenzophenone may have potential applications in the development of new drugs for various therapeutic targets. However, it is important to handle and use 5-fluoro-2-aminobenzophenone with caution, as it can be hazardous to health and the environment.

Upstream product

• 100-47-0 benzonitrile 
• 371-40-4 4-fluoroaniline 
• 98-88-4 benzoyl chloride 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 880875-39-8 2-amino-5-fluoro-N-methoxy-N-methylbenzamide 
• 100-58-3 phenylmagnesium bromide 
• 108-86-1 bromobenzene 
• 446-08-2 2-amino-5-fluorobenzoic acid 
• 61272-77-3 2-cyano-4-fluoroaniline 
• 873-55-2 sodium benzenesulfonate 
• 98-80-6 phenylboronic acid 
• 38520-78-4 6-fluoro-2-methyl-4H-benzo[d][1,3]oxazin-4-one 
• 321-69-7 5-fluoroisatoic anhydride 
• 1190310-35-0 5-fluoro-3-hydroxy-3-phenylindolin-2-one 

Downstream Products

• 674802-97-2 2-N-(4-methylsulfonylbenzoyl)-amide-5-fuoro-benzophenone 
• 462120-53-2 2-N-(4-aminosulfonylbenzoyl)-amide-5-fuoro-benzophenone 
• 91713-73-4 7-Benzoyl-5-fluoro-1,3-dihydro-indol-2-one 
• 91713-72-3 7-Benzoyl-5-fluoro-3-methylsulfanyl-1,3-dihydro-indol-2-one 
• 91714-78-2 Sodium; (2-amino-3-benzoyl-5-fluoro-phenyl)-acetate 
• 39573-16-5 5-fluoro-2-aminobenzophenone hydrazone 
• 1043425-39-3 2-amino-5-fluoro-3'-nitrobenzophenone 
• 1362019-81-5 (2R,3S,4R)-ethyl 6-fluoro-2-methyl-4-phenyl-1,2,3,4-tetrahydroquinoline-3-carboxylate 
• 1597443-30-5 (2-amino-5-fluorophenyl)phenylmethanone oxime 
• 2648-00-2 7-fluoro-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one 
• 844-16-6 Ro 05-4865 

Relevant articles and documents

One-Pot Synthesis of 2-Aminobenzophenones from 2-Alkynyl Arylazides Catalyzed by Pd and Cu Precursors

We describe a novel one-pot three-step reaction of 2-alkynyl arylazides through palladium-catalyzed formation of 3-hydroxy-3-phenylindolin-2-ones followed by hydrolysis of amide bonds and copper-catalyzed decarboxylation to give 2-aminobenzophenones. This synthetic method works well with various 2-alkynyl arylazides and affords the products in moderate to good yields under mild reaction conditions.

Deoxygenative Arylation of Carboxylic Acids by Aryl Migration

An unprecedented deoxygenative arylation of aromatic carboxylic acids has been achieved, allowing the construction of an enhanced library of unsymmetrical diaryl ketones. The synergistic photoredox catalysis and phosphoranyl radical chemistry allows for precise cleavage of a stronger C?O bond and formation of a weaker C?C bond by 1,5-aryl migration under mild reaction conditions. This new protocol is independent of substrate redox-potential, electronic, and substituent effects. It affords a general and promising access to 60 examples of synthetically versatile o-amino and o-hydroxy diaryl ketones under redox-neutral conditions. Furthermore, it also brings one concise route to the total synthesis of quinolone alkaloid, (±)-yaequinolone A2, and a viridicatin derivative in satisfying yields.

Palladium-Catalyzed Cascade Reductive and Carbonylative Cyclization of Ortho-Iodo-Tethered Methylenecyclopropanes (MCPs) Using N-Formylsaccharin as CO Source

A palladium-catalyzed reductive and carbonylative cyclization of ortho-iodo-tethered methylenecyclopropanes (MCPs) using N-formylsaccharin as CO source has been developed, affording the desired indanone derivatives in moderate to good yields with high regio- and stereoselectivity and good functional group compatibility.