61272-77-3Relevant articles and documents
Preparation method 2 -amino -5 -fluorobenzonitrile
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Paragraph 0027; 0031-0034; 0038; 0039; 0043, (2021/09/08)
The invention discloses a preparation method of 2 - amino -5 - fluorobenzonitrile, which comprises the specific steps of (1) taking 2, 5 - difluorobenzaldehyde as a starting raw material, condensation reaction with hydroxylamine hydrochloride under the conditions of triethylamine, and generating compound III. (2) Compound III is dehydrated with phosphorus oxychloride to form compound IV. (3) Compound IV is decomposed by ammonia to form compound I. That is 2 - amino -5 - fluorobenzonitrile. The preparation method is higher in yield.
A Homogeneous Method for the Conveniently Scalable Palladium- and Nickel-Catalyzed Cyanation of Aryl Halides
Burg, Finn,Egger, Julian,Deutsch, Johannes,Guimond, Nicolas
, p. 1540 - 1545 (2016/08/30)
Homogeneous conditions for the palladium-catalyzed cyanation of aryl halides were developed. This new system features a broad scope of aryl chlorides and bromides, uses 2-propanol or 1-butanol as solvent, and is readily scalable. The same conditions can also provide simple benzonitriles using the recently developed (TMEDA)NiCl(o-tolyl) precatalyst in conjunction with 1,1′-bis(diphenylphosphino)ferrocene (dppf) as a ligand.
3-Aminoindazole derivatives
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, (2008/06/13)
.Iadd.Pharmaceutical compositions having muscle relaxant and analgesic activity containing 3-aminoindazoles..Iaddend.