36268-59-4

Basic information

• Product Name: N-[2-(cyanomethyl)phenyl]acetamide
• Synonyms: N-[2-(cyanomethyl)phenyl]acetamide;2-(Acetylamino)phenylacetonitrile;2'-Cyanomethylacetanilide
• CAS NO: 36268-59-4
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.1992
• EINECS: 252-941-3
• Mol File: 36268-59-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 406.2°Cat760mmHg
• Flash Point: 199.5°C
• Appearance: /
• Density: 1.171g/cm³
• Vapor Pressure: 8.27E-07mmHg at 25°C
• Refractive Index: 1.587
• CAS DataBase Reference: N-[2-(cyanomethyl)phenyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(cyanomethyl)phenyl]acetamide(36268-59-4)
• EPA Substance Registry System: N-[2-(cyanomethyl)phenyl]acetamide(36268-59-4)

Safety Data

• Hazardous Substances Data: 36268-59-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H10N2O/c1-8(13)12-10-5-3-2-4-9(10)6-7-11/h2-5H,6H2,1H3,(H,12,13)

Upstream product

• 2973-50-4 2-aminophenylacetonitrile 
• 108-24-7 acetic anhydride 
• 58884-31-4 (2-diacetylamino-phenyl)-acetonitrile 
• 610-66-2 2-nitro-benzeneacetonitrile 

Downstream Products

• 51072-83-4 2-methyl-1H-indole-3-carbonitrile 
• 5784-95-2 2-(4-methoxyphenyl)-1H-indole 
• 948-65-2 2-phenyl-indole 
• 782-17-2 2-(4-fluorophenyl)indole 
• 55577-25-8 2-(4-methylphenyl)-1H-indole 
• 62641-44-5 N-(2-(2-oxo-2-phenylethyl)phenyl)acetamide 
• 847237-12-1 2-(3-methylphenyl)-1H-indole 
• 537684-22-3 2-o-tolyl-1H-indole 
• 1416969-58-8 2-(2,6-dimethylphenyl)-1H-indole 
• 521295-49-8 2-(4-(tert-butyl)phenyl)-1H-indole 
• 23746-79-4 2-(2'-chlorophenyl)-1H-indole 
• 1211-35-4 2-(4-chlorophenyl)-1H-indole 
• 6127-49-7 2-(4-bromophenyl)indole 
• 6202-59-1 2-(4-iodophenyl)-1H-indole 

Relevant articles and documents

Synihesis of 3-substituied indoles via a modified madeling reaction

Anilides 4a-c,e-k, lla-d in which the amide function is benzylated, or silylated and having different electron-withdrawing groups (EWG) at the methyl methyl in the ortho position of the amide function, cyclize under the influence of potassium tert-butoxide to the corresponding indole derivatives 5a-c,e-k and 9a-d, respectively, under these conditions the chloroacetamides 4d,n and 11e are converted into the tetrahydroquinolines 6a,b and 12, respectively. Treatment of chloroacetamide 4m with KOt-Bu gave, in addition to starting material, indole 5m, tetrahydroquinoline 6c and 2(1H)-quinolinone 7. When 3-indolecarbonitrile 5a is treated with sodium in liquid amnonia debenzylation takes place, while after catalytic hydrogenation with 5% Pd/C the corresponding 2,3-dirnethylindole 8 is formed.