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36282-47-0 Usage

Description

TRAMADOL HYDROCHLORIDE, also known as cis-Tramadol, is an opioid analgesic that functions by activating the μ-opioid receptor, inhibiting the reuptake of serotonin and norepinephrine, and blocking voltage-gated sodium channels. It is a white solid and is regulated as a Schedule IV compound in the United States. TRAMADOL HYDROCHLORIDE is primarily used for research and forensic applications.

Uses

Used in Pharmaceutical Industry:
TRAMADOL HYDROCHLORIDE is used as an analgesic for the treatment of moderate to severe pain. It works by targeting the μ-opioid receptor, which helps in reducing the perception of pain and providing relief.
Used in Research and Forensic Applications:
TRAMADOL HYDROCHLORIDE is used as an analytical reference material and a certified reference material in research and forensic applications. It aids in the development and validation of analytical methods, as well as in the identification and quantification of the compound in various samples.
Used in Pain Management:
TRAMADOL HYDROCHLORIDE is used as a pain management agent for patients suffering from chronic or acute pain. Its dual mechanism of action, involving the inhibition of serotonin and norepinephrine reuptake, along with the activation of the μ-opioid receptor, makes it an effective option for pain relief.
Used in Drug Development:
TRAMADOL HYDROCHLORIDE is used as a reference compound in the development of new drugs targeting the opioid receptor system. Its chemical properties and pharmacological effects serve as a basis for designing and synthesizing novel analgesic agents with improved efficacy and reduced side effects.

Check Digit Verification of cas no

The CAS Registry Mumber 36282-47-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,2,8 and 2 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 36282-47:
(7*3)+(6*6)+(5*2)+(4*8)+(3*2)+(2*4)+(1*7)=120
120 % 10 = 0
So 36282-47-0 is a valid CAS Registry Number.

InChI:InChI=1/C16H25NO2.ClH/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3;/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3;1H/t14-,16+;/m0./s1

36282-47-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name	Tramadol Hydrochloride

1.2 Other means of identification

Product number	-
Other names	Tramadol hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:36282-47-0 SDS

36282-47-0Upstream product

36282-47-0Downstream Products

36282-47-0Relevant articles and documents

Continuous-Flow Synthesis of Tramadol from Cyclohexanone

Monos, Timothy M.,Jaworski, Jonathan N.,Stephens, John C.,Jamison, Timothy F.

, p. 1888 - 1893 (2020/11/24)

A multioperation, continuous-flow platform for the synthesis of tramadol, ranging from gram to decagram quantities, is described. The platform is segmented into two halves allowing for a single operator to modulate between preparation of the intermediate by Mannich addition or complete the fully concatenated synthesis. All purification operations are incorporated in-line for the Mannich reaction. 'Flash' reactivity between meta-methoxyphenyl magnesium bromide and the Mannich product was controlled with a static helical mixer and tested with a combination of flow and batch-based and factorial evaluations. These efforts culminated in a rapid production rate of tramadol (13.7 g°h -1) sustained over 56 reactor volumes. A comparison of process metrics including E-Factor, production rate, and space-time yield are used to contextualize the developed platform with respect to established engineering and synthetic methods for making tramadol.

Across-the-World Automated Optimization and Continuous-Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud-Based Server

Fitzpatrick, Daniel E.,Maujean, Timothé,Evans, Amanda C.,Ley, Steven V.

supporting information, p. 15128 - 15132 (2018/10/31)

The power of the Cloud has been harnessed for pharmaceutical compound production with remote servers based in Tokyo, Japan being left to autonomously find optimal synthesis conditions for three active pharmaceutical ingredients (APIs) in laboratories in Cambridge, UK. A researcher located in Los Angeles, USA controlled the entire process via an internet connection. The constituent synthetic steps for Tramadol, Lidocaine, and Bupropion were thus optimized with minimal intervention from operators within hours, yielding conditions satisfying customizable evaluation functions for all examples.

COMPOSITIONS AND METHODS FOR OVERCOMING RESISTANCE TO TRAMADOL

-

Paragraph 0210, (2013/03/26)

There is disclosed a composition for oral administration of O-desmethyltramadol. There is further disclosed a method for treating disorders modulated by at least opiate receptor activity or monoamine activity, including acute and chronic pain, comprising administering a pharmaceutical formulation comprising O-desmethyltramadol. Compositions and methods are also provided that are effective for overcoming resistance to tramadol in patients.

CAS

36282-47-0