36438-63-8Relevant articles and documents
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Sulzbacher
, p. 5346 (1950)
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HETEROCYCLIC COMPOUNDS AS MUTANT IDH INHIBITORS
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Paragraph 0442; 0444, (2020/07/16)
The present disclosure relates generally to compounds useful in treatment of conditions associated with mutant isocitrate dehydrogenase (mt-IDH), particularly mutant IDH1 enzymes. Specifically, the present invention discloses compound of formula (IA), which exhibits inhibitory activity against mutant IDH1 enzymes. Method of treating conditions associated with excessive activity of mutant IDH1 enzymes with such compound is disclosed. Uses thereof, pharmaceutical composition, and kits are also disclosed.
Chemoenzymatic synthesis of enantiopure 1-phenyl-2-haloethanols and their esters
Lystvet, Sina Maria,Hoff, Bard Helge,Anthonsen, Thorleif,Jacobsen, Elisabeth Egholm
experimental part, p. 272 - 278 (2011/11/30)
Several secondary haloalcohols have been resolved by esterification catalyzed by lipases A and B from Candida antarctica (CALA and CALB, respectively). Immobilized CALB (Novozym 435) gave better selectivities and faster reaction rates than CALA (Novozyme