369-51-7

Basic information

• Product Name: 4-Fluorobenzenesulfinic acid sodium salt
• Synonyms: Benzenesulfinicacid, p-fluoro- (8CI); 4-Fluorobenzenesulfinic acid; p-Fluorobenzenesulfinicacid
• CAS NO: 369-51-7
• Molecular Formula: C₆H₅FO₂S
• Molecular Weight: 0
• Mol File: 369-51-7.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Fluorobenzenesulfinic acid sodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluorobenzenesulfinic acid sodium salt(369-51-7)
• EPA Substance Registry System: 4-Fluorobenzenesulfinic acid sodium salt(369-51-7)

Safety Data

• Hazardous Substances Data: 369-51-7(Hazardous Substances Data)

Upstream product

• 462-06-6 fluorobenzene 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 371-42-6 4-Fluorothiophenol 
• 125568-47-0 4-fluorobenzenesulfinic acid ethyl ester 
• 7446-09-5 sulfur dioxide 
• 824-80-6 sodium 4-fluorobenzenesulfinate 
• 50986-83-9 4-fluorobenzenesulfinyl chloride 

Downstream Products

• 125568-47-0 4-fluorobenzenesulfinic acid ethyl ester 
• 88576-31-2 3-(p-fluorophenylsulfonyl)-3-methyl-1-propene 
• 226396-71-0 2-(4-fluorobenzenesulfonyl)acetic acid methyl ester 
• 129961-95-1 2-(4-phenylsulfanyl-benzenesulfonyl)acetic acid methyl ester 
• 102914-99-8 2-(4-fluoro-benzenesulfonyl)-benzene-1,4-diol 
• 90357-06-5 Bicalutamide 
• 718-25-2 (E)-4-fluorostilbene 
• 39769-26-1 (E)-1-(4-fluorophenyl)-2-(4-chlorophenyl)ethene 
• 96426-60-7 methyl (2E)-3-(4-fluorophenyl)-2-propenoate 
• 345-83-5 4-fluorobenzophenone 
• 432-99-5 2-[(4-fluorophenyl)sulfonyl]-1-phenylethan-1-one 
• 782-17-2 2-(4-fluorophenyl)indole 
• 1613024-18-2 3-(((4-fluorophenyl)sulfonyl)methyl)-1,3-dimethylindolin-2-one 
• 1210054-34-4 3-[(4-fluorophenyl)thio]-1H-indole 

Relevant articles and documents

Photoredox Catalyzed Sulfonylation of Multisubstituted Allenes with Ru(bpy)3Cl2 or Rhodamine B

A highly regio- and stereoselective sulfonylation of allenes was developed that provided direct access to α, β-substituted unsaturated sulfone. By means of visible-light photoredox catalysis, the free radicals produced by p-toluenesulfonic acid reacted with multisubstituted allenes to obtain Markovnikov-type vinyl sulfones with Ru(bpy)3Cl2 or Rhodamine B as photocatalyst. The yield of this reaction could reach up to 91%. A series of unsaturated sulfones would be used for further transformation to some valuable compounds.

Hydrosulfonylation of Alkenes with Sulfonyl Chlorides under Visible Light Activation

Sulfonyl chlorides are inexpensive reactants extensively explored for functionalization, but never considered for radical hydrosulfonylation of alkenes. Herein, we report that tris(trimethylsilyl)silane is an ideal hydrogen atom donor enabling highly effective photoredox-catalyzed hydrosulfonylation of electron-deficient alkenes with sulfonyl chlorides. To increase the generality of this transformation, polarity-reversal catalysis (PRC) was successfully implemented for alkenes bearing alkyl substituents. This late-stage functionalization method tolerates a remarkably wide range of functional groups, is operationally simple, scalable, and allows access to building blocks which are important for medicinal chemistry and drug discovery.

Direct Substitution of Secondary and Tertiary Alcohols to Generate Sulfones under Catalyst- and Additive-Free Conditions

An environmentally benign protocol that affords propargylic sulfones containing highly congested carbon centers from easily accessible alcohols and sulfinic acids with water as the only byproduct is reported. The reaction proceeded via an in situ dehydrative cross-coupling process by taking advantage of the synergetic actions of multiple hydrogen bonds rather than relying on an external catalyst and/or additives to achieve high product distribution.