370-22-9

Basic information

• Product Name: 1,3-Bis(4-fluorophenyl)urea, 97%
• Synonyms: 1,3-Bis(4-fluorophenyl)urea, 97%
• CAS NO: 370-22-9
• Molecular Formula: C₁₃H₁₀F₂N₂O
• Molecular Weight: 248.2281064
• Mol File: 370-22-9.mol
• Article Data: 26

Chemical Properties

• Melting Point: 267 °C
• Boiling Point: 260.3°C at 760 mmHg
• Flash Point: 111.3°C
• Appearance: /
• Density: 1.392g/cm³
• Vapor Pressure: 0.0123mmHg at 25°C
• Refractive Index: 1.65
• CAS DataBase Reference: 1,3-Bis(4-fluorophenyl)urea, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Bis(4-fluorophenyl)urea, 97%(370-22-9)
• EPA Substance Registry System: 1,3-Bis(4-fluorophenyl)urea, 97%(370-22-9)

Safety Data

• Hazardous Substances Data: 370-22-9(Hazardous Substances Data)

Usage

General Description

1,3-Bis(4-fluorophenyl)urea, 97% is a chemical compound with a high purity level, often used in chemical and pharmaceutical research, among other applications. Its '97%' denomination signifies that the content of the main compound in the mixture is 97%, hence very pure, with very little impurity. The molecular structure of the compound features a urea group (NH2CONH2) bound to two fluorinated phenyl rings. Fluorine in the compound augments the stability due to the strong bond it forms, and the aromatic phenyl group improves the molecule's ability to interact with other entities in a system. The urea group contributes to its solubility in water, among other properties. Precise handling guidelines and safety precautions are necessary due to potentially harmful health effects from exposure.

InChI:InChI=1/C13H10F2N2O/c14-9-1-5-11(6-2-9)16-13(18)17-12-7-3-10(15)4-8-12/h1-8H,(H2,16,17,18)

Upstream product

• 351-74-6 bis(4-fluorophenyl)methanediimine 
• 107-97-1 sarcosine 
• 1195-45-5 para-fluorophenyl isocyanate 
• 2935-90-2 Methyl 3-mercaptopropionate 
• 126521-82-2 hexaamino-benzene trihydrochloride 
• 371-40-4 4-fluoroaniline 
• 105-45-3 acetoacetic acid methyl ester 
• 141-97-9 ethyl acetoacetate 
• 404-52-4 N,N’-di-(4-fluorophenyl)thiourea 
• 766-98-3 1-ethynyl-4-fluorobenzene 
• 98-95-3 nitrobenzene 
• 459-56-3 4-fluorobenzylic alcohol 
• 201230-82-2 carbon monoxide 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 86488-77-9 C₁₃H₉F₂N₃O₂ 
• 1960-13-0 1-({4-fluorophenyl}diazenyl)naphthalen-2-ol 
• 569-81-3 N-(4-fluorophenyl)phthalimide 
• 141417-89-2 N,N’-bis(4-fluorophenyl)formamidine 
• 351-74-6 bis(4-fluorophenyl)methanediimine 
• 371-40-4 4-fluoroaniline 

Relevant articles and documents

Di-tert-butyl peroxide (DTBP)-mediated synthesis of symmetrical N,N′-disubstituted urea/thiourea motifs from isothiocyanates in water

ABATRACT: A direct approach to N,N′-disubstituted urea/thiourea from the self-condensation reactions of isothiocyanates in water has been developed. This access tolerated a wide range of functional groups on the aromatic ring, providing a practical and environment-friendly process to N,N′-disubstituted urea/thiourea in moderate to excellent yields from safe and easily available starting materials. A plausible mechanism of the desulfurization self-condensation reaction for urea was also proposed and the role of di-tert-butyl peroxide (DTBP) and copper catalyst in the present strategy was demonstrated with the help of ESI mass spectrometry of intermediate studies.

Palladium-Catalyzed Aerobic Oxidative Carbonylation of Amines Enables the Synthesis of Unsymmetrical N,N′-Disubstituted Ureas

A ligand-free palladium-catalyzed aerobic oxidative carbonylation of amines for the synthesis of ureas, particular unsymmetrically N,N′-disubstituted ureas, which cannot be accessed by any other palladium-catalyzed oxidative carbonylation of amines to date, is presented. An array of symmetrical and unsymmetrical ureas were straightforwardly synthesized by using inexpensive, readily available, stable, and safe amines with good to excellent yields under a pressure of 1 atm. This novel method employs oxygen as the sole oxidant and offers an attractive alternative to transition-metal-based oxidant systems.

Hydrosilane-Assisted Synthesis of Urea Derivatives from CO2and Amines

A methodology employing CO2, amines, and phenylsilane was discussed to access aryl- or alkyl-substituted urea derivatives. This procedure was characterized by adopting hydrosilane to promote the formation of ureas directly, without the need to prepare silylamines in advance. Control reactions suggested that FeCl3 was a favorable additive for the generation of ureas, and this 1,5,7-triazabicyclo[4.4.0]dec-5-ene-catalyzed reaction might proceed through nucleophilic addition, silicon migration, and the subsequent formal substitution of silylcarbamate.