371244-11-0

Basic information

• Product Name: 4(3H)-Quinazolinone, 2-(chloroMethyl)-5-Methyl-3-(2-Methylphenyl)-
• Synonyms: 4(3H)-Quinazolinone, 2-(chloroMethyl)-5-Methyl-3-(2-Methylphenyl)-
• CAS NO: 371244-11-0
• Molecular Formula: C17H15ClN2O
• Molecular Weight: 298.7668
• Mol File: 371244-11-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4(3H)-Quinazolinone, 2-(chloroMethyl)-5-Methyl-3-(2-Methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(3H)-Quinazolinone, 2-(chloroMethyl)-5-Methyl-3-(2-Methylphenyl)-(371244-11-0)
• EPA Substance Registry System: 4(3H)-Quinazolinone, 2-(chloroMethyl)-5-Methyl-3-(2-Methylphenyl)-(371244-11-0)

Safety Data

• Hazardous Substances Data: 371244-11-0(Hazardous Substances Data)

Usage

General Description

4(3H)-Quinazolinone, 2-(chloroMethyl)-5-Methyl-3-(2-Methylphenyl)- is a chemical compound that belongs to the quinazolinone family. It has a molecular formula C17H16ClN3O and a molecular weight of 309.78 g/mol. 4(3H)-Quinazolinone, 2-(chloroMethyl)-5-Methyl-3-(2-Methylphenyl)- is a heterocyclic organic compound with potential applications in the pharmaceutical industry as it is a building block for the synthesis of various biologically active compounds. The presence of chloromethyl and methyl groups makes it potentially useful for medicinal chemistry and drug discovery efforts. Further research and analysis of this compound may lead to the development of new pharmaceuticals with therapeutic potential.

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Relevant articles and documents

Design and synthesis of 1,4-substituted 1H-1,2,3-triazolo-quinazolin-4(3H)-ones by Huisgen 1,3-dipolar cycloaddition with PI3Kγ isoform selective activity

A strategy for construction of medicinally important 1,4-substituted 1H-1,2,3-triazolo-quinazolin-4(3H)-ones has been devised and presented here. The compounds have been synthesized using one-pot multicomponent strategy under microwave assisted conditions. Triazolyl-quinazolinone based D-ring modified analogs are designed based on IC87114 scaffold, which is first known isoform selective inhibitor of PI3Kδ. Herein, we identified two triazolyl-quinazolinone compounds (5a and 5l) based on same scaffold with PI3Kγ specific inhibitory potential, the selectivity towards this isoform is well supported by in silico results, wherein, these compounds show better interaction and affinity and inhibitory activity for PI3Kγ rather than PI3Kδ. This repositioning of scaffold from PI3Kδ to PI3Kγ isoform can be very useful from medicinal chemistry and drug discovery perspective to unravel molecular interactions of this new scaffold in different cellular pathways.

One-pot multicomponent synthesis of medicinally important purine quinazolinone derivatives

Herein, a protocol that involves microwave-assisted, multicomponent one-pot synthetic strategy for the construction of the medicinally important purine quinazolinone scaffold is reported. A series of compounds are prepared by cyclization and condensation

METHODS AND COMPOSITIONS FOR TREATMENT OF OPHTHALMIC CONDITIONS

The present invention provides chemical entities or compounds and pharmaceutical compositions thereof that are capable of modulating signal transduction by certain protein kinases such as mTor, tyrosine kinases, and/or lipid kinases such as PB kinase in a