37854-32-3Relevant articles and documents
Synthesis of non-THF analogs of acetogenin toward simplified mimics
Fujita, Daisuke,Ichimaru, Naoya,Abe, Masato,Murai, Masatoshi,Hamada, Takeshi,Nishioka, Takaaki,Miyoshi, Hideto
, p. 5775 - 5779 (2005)
Acetogenin analogs in which the bis-adjacent THF ring was replaced with an enantioselectively synthesized 1,2-cyclopentanediol bis-ether skeleton were synthesized to obtain simplified mimics, and their inhibitory effect on mitochondrial NADH-ubiquinone oxidoreductase (complex I) was examined. The results clearly demonstrate that the 1,2-cyclopentanediol bis-ether motif can substitute for the bis-THF ring while maintaining very potent inhibitory activity at the nanomolar level.
Direct one step mono-functionalisation of symmetrical 1,2-diols
Clarke, Paul A.,Holton, Robert A.,Kayaleh, Nadim E.
, p. 2687 - 2690 (2007/10/03)
The mono-functionalisation of meso- and C2-symmetric diols has been achieved via the use of a new lanthanide(III) chloride catalysed acylation reaction. (C) 2000 Elsevier Science Ltd.