383-29-9

Basic information

• Product Name: 4-Fluorophenyl sulfone
• Synonyms: 1,1’-sulfonylbis[4-fluoro-benzen;1-Fluoro-4-[(4-fluorophenyl)sulfonyl]benzene;Benzene, 1,1'-sulfonylbis*4-fluoro-;Benzene, 1,1'-sulfonylbis[4-fluoro-;Sulfone, bis(p-fluorophenyl);P-FLUOROPHENYL SULFONE;4-FLUOROPHENYL SULPHONE;4-FLUOROPHENYL SULFONE
• CAS NO: 383-29-9
• Molecular Formula: C₁₂H₈F₂O₂S
• Molecular Weight: 254.25
• EINECS: 206-847-4
• Product Categories: Diphenyl Sulfones (for High-Performance Polymer Research);Functional Materials;Reagent for High-Performance Polymer Research
• Mol File: 383-29-9.mol
• Article Data: 22

Chemical Properties

• Melting Point: 98-100 °C(lit.)
• Boiling Point: 367.9 °C at 760 mmHg
• Flash Point: 176.3 °C
• Appearance: White to brown/Crystals or Powder
• Density: 1.3538 (estimate)
• Vapor Pressure: 0.00983mmHg at 25°C
• Refractive Index: 1.496
• Storage Temp.: Store below +30°C.
• Solubility: soluble in Methanol
• BRN: 1970911
• CAS DataBase Reference: 4-Fluorophenyl sulfone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluorophenyl sulfone(383-29-9)
• EPA Substance Registry System: 4-Fluorophenyl sulfone(383-29-9)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 22-24/25
• WGK Germany: 3
• TSCA: T
• HazardClass: IRRITANT
• Hazardous Substances Data: 383-29-9(Hazardous Substances Data)

Usage

Description

4-Fluorophenyl sulfone is an organic compound characterized by its white to brown crystalline or powdery appearance. It is known for its chemical properties that make it suitable for various applications, particularly in the field of chemistry and material science.

Uses

Used in Chemical Synthesis:
4-Fluorophenyl sulfone is used as a synthetic intermediate for the production of various chemical compounds. Its reactivity in substitution reactions with deprotonated amines makes it a valuable building block in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Fluorophenyl sulfone is utilized as a key component in the development of new drugs. Its unique chemical properties allow it to be incorporated into the molecular structures of potential therapeutic agents, contributing to their overall efficacy and selectivity.
Used in Material Science:
4-Fluorophenyl sulfone is also employed in the field of material science, where it is used to create novel materials with specific properties. Its ability to participate in substitution reactions enables the development of materials with tailored characteristics, such as improved stability, reactivity, or selectivity.

InChI:InChI=1/C9H6BrF3O/c10-5-8(14)6-1-3-7(4-2-6)9(11,12)13/h1-4H,5H2

Upstream product

• 462-06-6 fluorobenzene 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 404-38-6 4,4'-difluorodiphenyl sulfide 
• 395-25-5 bis(4-fluorophenyl)sulfoxide 
• 1156-50-9 4-nitrophenyl sulfone 
• 7790-94-5 chlorosulfonic acid 
• 368-88-7 4-fluorobenzenesulfonic acid 
• 80-09-1 4,4'-sulfonediphenol 
• 17763-90-5 4,4'-sulfonylbis(phenyltrifluoromethanesulfonate) 
• 824-80-6 sodium 4-fluorobenzenesulfinate 
• 460-00-4 1-Bromo-4-fluorobenzene 

Downstream Products

• 339-25-3 1-fluoro-4-((4-methoxyphenyl)sulfonyl)benzene 
• 312-30-1 3,3'-dinitro-4,4'-difluorodiphenyl sulphone 
• 312-35-6 4-[(4-fluorophenyl)sulfonyl]benzeneamine 
• 87014-32-2 Bis sulfone 
• 96308-23-5 C₁₄H₁₀F₄O₃S 
• 81943-93-3 di(pyridyloxy-3)-4,4' diphenylsulfone 
• 917868-79-2 4-fluoro-4'-(4''-methoxyphenyloxy)diphenyl sulfone 
• 34018-55-8 4,4'-(4'',4'''-dimethoxyphenyloxy)diphenyl sulfone 
• 917868-81-6 C₂₉H₂₈O₅S 
• 917868-82-7 4-{4-[4-(4-tert-butyl-phenoxy)-benzenesulfonyl]-phenoxy}-phenol 
• 917868-83-8 C₄₇H₄₀O₉S₂ 
• 917868-90-7 C₆₂H₄₆O₁₄S₃ 
• 19896-27-6 4,4'-Bis-(4-hydroxyphenoxy)-diphenylsulfon 
• 1247029-28-2 4-[4-(4-fluoro-benzenesulfonyl)-phenylamino]-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Selective synthesis of sulfoxides and sulfonesviacontrollable oxidation of sulfides withN-fluorobenzenesulfonimide

A practical and mild method for the switchable synthesis of sulfoxides or sulfonesviaselective oxidation of sulfides using cheapN-fluorobenzenesulfonimide (NFSI) as the oxidant has been developed. These highly chemoselective transformations were simply achieved by varying the NFSI loading with H2O as the green solvent and oxygen source without any additives. The good functional group tolerance makes the strategy valuable.

One-pot fluorosulfurylation of Grignard reagents using sulfuryl fluoride

Herein, we report a new method for the one-pot syntheses of sulfonyl fluorides. Addition of an alkyl, aryl, or heteroaryl Grignard to a solution of sulfuryl fluoride at ambient temperature affords the desired sulfonyl fluorides in 18-78% yield. Furthermore, this method is applicable for in situ sequential reactions, whereby the Grignard reagent can be converted to the corresponding diarylsulfone, sulfonate ester, or sulfonamide in a one-pot process.

The synthesis of diarylsulfones with simple arenes and K2S2O8 through double C-S bond formation

An unprecedented double C-S bond formation method has been developed to prepare both symmetric and unsymmetric diarylsulfones with simple arenes in a single step. This represents the first example that K2S2O8 can be employed as a highly effective sulfonating agent to synthesize diarylsulfones. The reaction demonstrates excellent reactivity, good functional group tolerance and high yields.