38449-49-9

Basic information

• Product Name: 2,3-DIHYDRO-2-THIOXO-4-THIAZOLEACETIC ACID ETHYL ESTER
• Synonyms: 2,3-dihydro-2-thioxo-4-thiazoleaceticaciethylester;4-ETHOXYCARBONYLMETHYL-4-THIAZOLINE-2-THIONE;2,3-DIHYDRO-2-THIOXO-4-THIAZOLEACETIC ACID ETHYL ESTER;ethyl 2,3-dihydro-2-thioxothiazol-4-acetate;2,3-DIHYDRO-2-THIOXO-4-THIAZOLEACETIC ACID ETHYL ESTER 96%;2,3-Dihydro-2-thioxo-4-thiazoleacetic acid ethyl ester,96%
• CAS NO: 38449-49-9
• Molecular Formula: C₇H₉NO₂S₂
• Molecular Weight: 203.28
• EINECS: 253-937-4
• Mol File: 38449-49-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 136-144 °C
• Boiling Point: 304.1°Cat760mmHg
• Flash Point: 137.7°C
• Appearance: /
• Density: 1.3988 (rough estimate)
• Vapor Pressure: 0.00089mmHg at 25°C
• Refractive Index: 1.6100 (estimate)
• PKA: 7.86±0.40(Predicted)
• CAS DataBase Reference: 2,3-DIHYDRO-2-THIOXO-4-THIAZOLEACETIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIHYDRO-2-THIOXO-4-THIAZOLEACETIC ACID ETHYL ESTER(38449-49-9)
• EPA Substance Registry System: 2,3-DIHYDRO-2-THIOXO-4-THIAZOLEACETIC ACID ETHYL ESTER(38449-49-9)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 38449-49-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H9NO2S2/c1-2-10-6(9)3-5-4-12-7(11)8-5/h4H,2-3H2,1H3,(H,8,11)

Upstream product

• 89910-38-3 (4-hydroxy-2-thioxo-thiazolidin-4-yl)-acetic acid ethyl ester 
• 638-07-3 ethyl (2-chloroaceto)acetate 
• 513-74-6 ammonium dithiocarbamate 
• 41665-64-9 bis-(4-ethoxycarbonylmethyl-thiazol-2-yl)-disulfide 
• 16687-42-6 ammonium thiocarbamate 

Downstream Products

• 36365-79-4 (2-thioxo-2,3-dihydro-thiazol-4-yl)-acetic acid 
• 123999-60-0 6,7-dihydro-6-oxo-4-phenyl-5H-thiazolo<4,3,2-d,e>thiazolo<3,4-a>pyrimidinium benzenesulfonate 
• 36365-79-4 2-mercapto-1,3-thiazol-4-yl-acetic acid 
• 194928-82-0 (6R,7R)-3-(4-Carbamoylmethyl-thiazol-2-ylsulfanyl)-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 

Relevant articles and documents

Thiazole- and imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase

Mimetics of the C-terminal CAAX tetrapeptide of Ras protein were designed replacing internal dipeptide AA with 4-amino-2-phenylbenzoic acid and cysteine (C) with 2-amino-4-thiazolyl-, 2-mercapto-4-thiazolyl-, 2-mercapto-4-imidazolyl- and 2-methylmercapto-4-thiazolyl-acetic or propionic acid. The compound in which C is replaced by 2-amino-4-thiazolylacetic acid inhibited FTase activity in the low nanomolar range and showed antiproliferative effect on rat aortic smooth muscle cells interfering with Ras farnesylation. On the basis of these results, 2-aminothiazole can be considered as an alternative to heterocycles, such as pyridine and imidazole, normally used in FTase inhibitors designed as non-thiol CAAX mimetics.

CARBOXYLIC ACID DERIVATIVE CONTAINING THIAZOLE RING AND PHARMACEUTICAL USE THEREOF

According to the present invention, a compound represented by the following formula (I) having a superior PPARα, agonist action and concurrently showing a hypolipidemic action can be provided, and further, a compound useful as a synthetic intermediate for the compound can be provided.

REDUCTIVE CLEAVAGE OF SYMMETRICAL DISULFIDES WITH HYDRAZINES

An efficient method for the reductive cleavage of symmetrical disulfides with hydrazines is described.