397246-12-7 Usage
Description
(R)-2-TERT-BUTYLOXYCARBONYLAMINO-PENTANE-1,5-DIOL, also known as Fmoc-L-lysine-OH, is an amino acid derivative that plays a significant role in organic synthesis and peptide chemistry. It is the protected form of L-lysine, featuring the Fmoc (9-fluorenylmethyloxycarbonyl) group as a protective agent for the amine functional group. This chemical compound is widely recognized for its utility as a building block in the synthesis of peptides, peptidomimetics, natural products, and pharmaceuticals. Its stability and ease of synthesis make it a popular choice as a reagent in solid-phase peptide synthesis.
Uses
Used in Pharmaceutical Industry:
(R)-2-TERT-BUTYLOXYCARBONYLAMINO-PENTANE-1,5-DIOL is used as a building block for the synthesis of various pharmaceuticals, given its role in creating peptides and peptidomimetics. (R)-2-TERT-BUTYLOXYCARBONYLAMINO-PENTANE-1,5-DIOL contributes to the development of new drugs by providing a stable and easily synthesized foundation for medicinal chemistry.
Used in Organic Synthesis:
In the field of organic synthesis, (R)-2-TERT-BUTYLOXYCARBONYLAMINO-PENTANE-1,5-DIOL serves as a crucial component for creating complex organic molecules. Its protective Fmoc group allows for selective reactions, making it a valuable asset in the synthesis of a wide range of organic compounds.
Used in Peptide Chemistry:
(R)-2-TERT-BUTYLOXYCARBONYLAMINO-PENTANE-1,5-DIOL is used as a building block for the synthesis of peptides. (R)-2-TERT-BUTYLOXYCARBONYLAMINO-PENTANE-1,5-DIOL's protected form of L-lysine enables the formation of peptide bonds in a controlled manner, which is essential for the development of peptide-based therapeutics and other applications.
Used in Solid-Phase Peptide Synthesis:
As a reagent in solid-phase peptide synthesis, (R)-2-TERT-BUTYLOXYCARBONYLAMINO-PENTANE-1,5-DIOL is utilized for its stability and ease of synthesis. This method of peptide synthesis is highly valued for its efficiency and the ability to create large quantities of peptides with minimal side reactions, thanks in part to the use of this compound.
Used in the Synthesis of Natural Products:
(R)-2-TERT-BUTYLOXYCARBONYLAMINO-PENTANE-1,5-DIOL is also used in the preparation of various natural products. Its role in peptide and organic synthesis makes it a versatile tool for creating complex natural compounds with potential applications in the fields of medicine, agriculture, and other industries.
Check Digit Verification of cas no
The CAS Registry Mumber 397246-12-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,9,7,2,4 and 6 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 397246-12:
(8*3)+(7*9)+(6*7)+(5*2)+(4*4)+(3*6)+(2*1)+(1*2)=177
177 % 10 = 7
So 397246-12-7 is a valid CAS Registry Number.
397246-12-7Relevant articles and documents
Synthetic process of anti-hyperglycemic drug intermediate R-3-amino-piperidine dihydrochloride
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Paragraph 0056-0059, (2019/11/12)
The invention relates to a synthetic process of an anti-hyperglycemic drug intermediate R-3-amino-piperidine dihydrochloride. The synthetic process comprises the steps: using inexpensive L-glutamic acid as a starting material, and performing esterification, amino protection, reduction, hydroxyl protection, substitution, cyclization and removal of protecting groups for amino groups so as to obtainthe R-3-amino-piperidine dihydrochloride. Compared with the prior art, the synthetic process has cheap and easily available raw materials, good selectivity, good atomic economy, high total yield and mild reaction conditions, and is suitable for industrial production.
CALPAIN MODULATORS AND METHODS OF PRODUCTION AND USE THEREOF
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, (2017/09/27)
The present technology relates to compounds, kits, compositions, and methods useful for the treatment of fibrotic disease. In some aspects, the present technology provides for treatment of various diseases or disorders associated or mediated, at least in part, by calpains, such as CAPN1, CAPN2, and/or CAPN9. The present technology is generally applicable to compounds which inhibit myofibroblast differentiation.
Amino-protected (R) - 3-amino-piperidine preparation method
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Paragraph 0050-0052, (2017/03/18)
The invention discloses a preparation method of amino protection (R)-3-amino piperidine, and the preparation method comprises the following steps: (1) in the presence of a first solvent or absence of a solvent, reacting a compound of formula V with benzylamine to obtain a compound of formula VI; (2) in the presence of a second solvent, performing catalytic hydrogenation of the compound of formula VI to remove benzyl to obtain the amino protection (R)-3-amino piperidine. According to the method, the defects of use of expensive metal catalysts and use of high-pressure hydrogenation and various splitting for synthesis of a chiral amino piperidine ring can be avoided, at the same time, the synthetic route is short, the process is simple, the yield is high, and the method is suitable for industrial mass production.
