401-12-7

Basic information

• Product Name: ethyl (Z)-2-acetamido-3-(4-fluorophenyl)acrylate
• Synonyms: ethyl (Z)-2-acetamido-3-(4-fluorophenyl)acrylate
• CAS NO: 401-12-7
• Molecular Weight: 251.257
• Mol File: 401-12-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl (Z)-2-acetamido-3-(4-fluorophenyl)acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (Z)-2-acetamido-3-(4-fluorophenyl)acrylate(401-12-7)
• EPA Substance Registry System: ethyl (Z)-2-acetamido-3-(4-fluorophenyl)acrylate(401-12-7)

Safety Data

• Hazardous Substances Data: 401-12-7(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 125772-83-0 (Z)-4-(4-fluorobenzylidene)-2-methyloxazol-5(4H)-one 
• 459-57-4 4-fluorobenzaldehyde 
• 360-23-6 N-benzenesulfonyl-N'-(4-fluoro-benzoyl)-hydrazine 
• 166116-63-8 4-(4-fluoro-benzylidene)-2-methyl-4H-oxazol-5-one 

Downstream Products

• 1416248-23-1 C₁₉H₁₉F₂NO₃ 
• 111649-72-0 α-acetylamino-4-fluoro-cinnamic acid 

Relevant articles and documents

Synthesis of Indole-2-carboxylate Derivatives via Palladium-Catalyzed Aerobic Amination of Aryl C-H Bonds

A direct oxidative C-H amination affording 1-acetyl indolecarboxylates starting from 2-acetamido-3-arylacrylates has been achieved. Indole-2-carboxylates can be targeted with a straightforward deacetylation of the initial reaction products. The C-H amination reaction is carried out using a catalytic Pd(II) source with oxygen as the terminal oxidant. The scope and application of this chemistry is demonstrated with good to high yields for numerous electron-rich and electron-poor substrates. Further reaction of selected products via Suzuki arylation and deacetylation provides access to highly functionalized indole structures.