402-46-0

Basic information

• Product Name: 4-Fluorobenzenesulfonamide
• Synonyms: p-fluoro-benzenesulfonamid;p-fluorobenzenesulphonamide;Benzenesulfonamide, 4-fluoro- (9CI);p-Fluorobenzenesulfonamide (PFSA);4-Fluorobenzenesulphonamide97%;4-FLUROBENZENESULFONAMIDE;4-FLUOROBENZENESULFONAMIDE 97%;4-fluorobenzene-1-sulfonaMide
• CAS NO: 402-46-0
• Molecular Formula: C₆H₆FNO₂S
• Molecular Weight: 175.18
• EINECS: 206-946-2
• Product Categories: SULFONAMIDE;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het;Organic Building Blocks;Sulfonamides/Sulfinamides;Sulfur Compounds
• Mol File: 402-46-0.mol
• Article Data: 29

Chemical Properties

• Melting Point: 124-127 °C(lit.)
• Boiling Point: 307.9 °C at 760 mmHg
• Flash Point: 140 °C
• Appearance: /
• Density: 1.428 g/cm³
• Vapor Pressure: 0.000705mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 10.00±0.10(Predicted)
• Water Solubility: It is soluble in water.
• CAS DataBase Reference: 4-Fluorobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluorobenzenesulfonamide(402-46-0)
• EPA Substance Registry System: 4-Fluorobenzenesulfonamide(402-46-0)

Safety Data

• Hazard Codes: T,Xi
• Statements: 23/24/25-36/37/38
• Safety Statements: 26-36-45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: DB2630000
• HazardClass: IRRITANT
• Hazardous Substances Data: 402-46-0(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 402-46-0 differently. You can refer to the following data:
1. 4-Fluorobenzenesulfonamide, is used to produce bis-(4-fluoro-benzenesulfonyl)-amine with 4-fluoro-benzenesulfonyl chloride at temperature of 55 - 60. This reaction will need reagent OH-.
2. 4-Fluorobenzenesulfonamide may be used to synthesize 4-fluorophenylsulfonyldithiocarbimate potassium dihydrate and amino-substituted sulfanilamide derivatives.

General Description

4-Fluorobenzenesulfonamide is a para-halogen benzenesulfonamide. Ab initio Hartree-Fock (HF) and density functional theory (DFT) have been used to investigate the structural features of 4-fluorobenzenesulfonamide.

InChI:InChI=1/C6H6FNO2S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,(H2,8,9,10)

Upstream product

• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 24850-33-7 allyltributylstanane 
• 10493-33-1 4-fluorobenzenesulfonyl azide 
• 76-63-1 allytriphenyltin 
• 29083-05-4 N-(tert-butyl)-4-fluorobenzenesulfonamide 
• 462-06-6 fluorobenzene 
• 368-85-4 4-fluorobenzenesulfonyl fluoride 
• 349-89-3 p-chlorobenzenesulfonyl fluoride 
• 824-80-6 sodium 4-fluorobenzenesulfinate 
• 371-42-6 4-Fluorothiophenol 
• 459-45-0 4-fluorobenzenediazonium tetrafluoroborate 
• 503596-47-2 N-sulfinyltriphenylmethylamine 
• 2592-95-2 benzotriazol-1-ol 
• 371-40-4 4-fluoroaniline 

Downstream Products

• 1525-81-1 4-fluoro-benzenesulfonic acid-(trichlorophosphoranyliden-amide) 
• 780-99-4 (4-fluoro-benzenesulfonyl)-carbamic acid ethyl ester 
• 719-15-3 4-fluoro-benzenesulfonic acid-(2,3-dihydroxy-propylamide) 
• 3895-25-8 4-fluorophenylsulfonyl isocyanate 
• 52072-72-7 N-fluoro-4-fluorobenzenesulfonamide 
• 52893-51-3 N,4-difluoro-N-[(4-fluorophenyl)sulfonyl]benzenesulfonamide 
• 3830-31-7 3-(p-fluorobenzenesulfonyl)-1-butylurea 
• 104448-64-8 2-Ethyl-hexanoic acid {1-[4-(4-fluoro-benzenesulfonylaminocarbonyl)-2-methoxy-benzyl]-1H-indol-6-yl}-amide 
• 102607-94-3 N-([(4-chlorophenyl)amino]carbonyl)-4-fluorobenzenesulfonamide 
• 105899-98-7 N-<(p-fluorophenyl)sulfonyl>-P,P,P-triphenylphospha-λ⁵-azene 
• 86151-02-2 4-Fluoro-N-(1-methyl-5-nitro-1H-imidazol-2-yl)-benzenesulfonamide 
• 2260-80-2 1-Cyclohexyl-3-p-fluorbenzolsulfonylharnstoff 
• 169894-65-9 N-(4-fluorophenylsulfonyl)benzamide 
• 186800-76-0 N-benzylidene-4-fluorobenzenesulfonamide 

Relevant articles and documents

Nickel(II)-Catalyzed Addition of Aryl and Heteroaryl Boroxines to the Sulfinylamine Reagent TrNSO: The Catalytic Synthesis of Sulfinamides, Sulfonimidamides, and Primary Sulfonamides

We report a redox-neutral Ni(II)-catalyzed addition of (hetero)aryl boroxines to N-sulfinyltritylamine (TrNSO). The reactions use a catalyst generated from the combination of commercial, air-stable NiCl2·(glyme) and a commercially available bipyridine lig

Radical Decarboxylative Carbometalation of Benzoic Acids: A Solution to Aromatic Decarboxylative Fluorination

Abundant aromatic carboxylic acids exist in great structural diversity from nature and synthesis. To date, the synthetically valuable decarboxylative functionalization of benzoic acids is realized mainly by transition-metal-catalyzed decarboxylative cross couplings. However, the high activation barrier for thermal decarboxylative carbometalation that often requires 140 °C reaction temperature limits both the substrate scope as well as the scope of suitable reactions that can sustain such conditions. Numerous reactions, for example, decarboxylative fluorination that is well developed for aliphatic carboxylic acids, are out of reach for the aromatic counterparts with current reaction chemistry. Here, we report a conceptually different approach through a low-barrier photoinduced ligand to metal charge transfer (LMCT)-enabled radical decarboxylative carbometalation strategy, which generates a putative high-valent arylcopper(III) complex, from which versatile facile reductive eliminations can occur. We demonstrate the suitability of our new approach to address previously unrealized general decarboxylative fluorination of benzoic acids.

Fluorescence Assisted Capillary Electrophoresis of Glycans Enabled by the Negatively Charged Auxochromes in 1-Aminopyrenes

A compact and negatively charged acceptor group, N-(cyanamino)sulfonyl, is introduced for dye design and its influence on the absorption and emission spectra of the “push–pull” chromophores is demonstrated with 1,3,6-tris[(cyanamino)sulfonyl]-8-aminopyrene. The new sulfonamides, including O-phosphorylated (3-hydroxyazetidine)-N-sulfonyl, are negatively charged electron acceptors and auxochromes. 1-Aminopyrenes decorated with the new sulfonamides have three or six negative charges (pH ≥8), low m/z ratios, high mobilities in an electric field, and yellow to orange emission. We labeled maltodextrin oligomers by reductive amination, separated the products by electrophoresis, and demonstrated their high brightness in a commercial DNA analyzer and the distribution of the emission signal among the detection channels.