408502-43-2

Basic information

• Product Name: 3-Bromo-2-iodopyridine
• Synonyms: 3-BROMO-2-IODOPYRIDINE;2-iodo-3-bromopyridine
• CAS NO: 408502-43-2
• Molecular Formula: C₅H₃BrIN
• Molecular Weight: 283.89
• Product Categories: Pyridine series;Halides;Pyridines
• Mol File: 408502-43-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 264°Cat760mmHg
• Flash Point: 113.5°C
• Appearance: /
• Density: 2.347g/cm³
• Refractive Index: 1.665
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 3-Bromo-2-iodopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-2-iodopyridine(408502-43-2)
• EPA Substance Registry System: 3-Bromo-2-iodopyridine(408502-43-2)

Safety Data

• Hazardous Substances Data: 408502-43-2(Hazardous Substances Data)

Usage

General Description

3-Bromo-2-iodopyridine is a chemical compound with the molecular formula C5H3BrIN2. It is a heterocyclic organic compound that consists of a pyridine ring substituted with bromine and iodine atoms at the 3rd and 2nd positions, respectively. 3-Bromo-2-iodopyridine is commonly used as a building block in organic synthesis and pharmaceutical research. It can be used as a reagent in various chemical reactions, such as cross-coupling reactions, which are important in the synthesis of pharmaceuticals and agrochemicals. 3-Bromo-2-iodopyridine is also utilized in the development of new materials, including organic light-emitting diodes (OLEDs) and liquid crystal displays (LCDs), due to its unique electronic properties. Additionally, it is important to handle this chemical with caution, as it is potentially hazardous and should be used in a controlled laboratory environment.

InChI:InChI=1/C5H3BrIN/c6-4-2-1-3-8-5(4)7/h1-3H

Upstream product

• 626-55-1 3-Bromopyridine 
• 52200-48-3 3-bromo-2-chloropyridine 
• 13534-89-9 2,3-dibromopyridine 
• 77332-76-4 2-chloro-3-(trimethylsilyl)pyridine 
• 7553-56-2 iodine 

Downstream Products

• 922501-62-0 dimethyl(phenylethynyl)[2-(phenylethynyl)pyridin-3-yl]silane 
• 131747-43-8 2-(trifluoromethyl)nicotinic acid 
• 1392013-91-0 2,3-bis(phenylethynyl)pyridine 

Relevant articles and documents

AROMATIC FUSED RING COMPOUND AND ORGANIC LIGHT EMITTING DEVICE USING THE SAME

The present invention relates to an aromatic condensed-ring compound and an organic light-emitting device using the same. In the present invention, provided is the compound represented by chemical formula 1. The compound described in the present specifica

Continuous flow magnesiation of functionalized heterocycles and acrylates with TMPMgCl·LiCl

A flow procedure for the metalation of functionalized heterocycles (pyridines, pyrimidines, thiophenes, and thiazoles) and various acrylates using the strong, non-nucleophilic base TMPMgCl·LiCl is reported. The flow conditions allow the magnesiations to be performed under more convenient conditions than the comparable batch reactions, which often require cryogenic temperatures and long reaction times. Moreover, the flow reactions are directly scalable without further optimization. Metalation under flow conditions also allows magnesiations that did not produce the desired products under batch conditions, such as the magnesiation of sensitive acrylic derivatives. The magnesiated species are subsequently quenched with various electrophiles, thereby introducing a broad range of functionalities. Go with the flow: Flow conditions allow a practical metalation of functionalized heterocycles and various acrylates in the presence of the base TMPMgCl·LiCl (TMP=2,2,6,6-tetramethylpiperidyl). More convenient temperatures and very fast reaction times can usually be achieved by applying the flow conditions. Sensitive acrylic derivatives can be magnesiated under flow conditions. Furthermore, the flow reactions are readily scalable without further optimization.

Deprotonative metalation of chloro- and bromopyridines using amido-based bimetallic species and regioselectivity-computed CH acidity relationships

A series of chloro- and bromopyridines have been deprotometalated by using a range of 2,2,6,6-tetramethylpiperidino-based mixed lithium-metal combinations. Whereas lithium-zinc and lithium-cadmium bases afforded different mono- and diiodides after subsequent interception with iodine, complete regioselectivities were observed with the corresponding lithium-copper combination, as demonstrated by subsequent trapping with benzoyl chlorides. The obtained selectivities have been discussed in light of the CH acidities of the substrates, determined both in the gas phase and as a solution in THF by using the DFT B3LYP method.