42351-88-2

Basic information

• Product Name: 2-tert-butylpyriMidin-4(1H)-one
• Synonyms: 2-tert-butylpyriMidin-4(1H)-one;4(1H)-PyriMidinone, 2-(1,1-diMethylethyl)-;2-(tert-Butyl)pyriMidin-4(3H)-one
• CAS NO: 42351-88-2
• Molecular Formula: C₈H₁₂N₂O
• Molecular Weight: 152.19368
• Mol File: 42351-88-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 236.6°C at 760 mmHg
• Flash Point: 96.9°C
• Appearance: /
• Density: 1.071g/cm³
• Vapor Pressure: 0.0306mmHg at 25°C
• Refractive Index: 1.528
• CAS DataBase Reference: 2-tert-butylpyriMidin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-tert-butylpyriMidin-4(1H)-one(42351-88-2)
• EPA Substance Registry System: 2-tert-butylpyriMidin-4(1H)-one(42351-88-2)

Safety Data

• Hazardous Substances Data: 42351-88-2(Hazardous Substances Data)

Usage

General Description

2-tert-butylpyrimidin-4(1H)-one is a chemical compound with the molecular formula C9H14N2O. It is a heterocyclic compound that contains a pyrimidine ring with a tert-butyl group attached to the second carbon atom. 2-tert-butylpyriMidin-4(1H)-one is used in organic synthesis and pharmaceutical research as a building block for the synthesis of various biologically active molecules. It also exhibits potential pharmacological properties, making it of interest in drug discovery and development. Additionally, 2-tert-butylpyrimidin-4(1H)-one has been studied for its potential applications in the agricultural industry as a pesticide or herbicide. Overall, this compound has diverse uses in the fields of chemistry, pharmaceuticals, and agriculture.

InChI:InChI=1/C8H12N2O/c1-8(2,3)7-9-5-4-6(11)10-7/h4-5H,1-3H3,(H,9,10,11)

Upstream product

• 85929-94-8 5-Bromo-2-(1,1-dimethylethyl)pyrimidine 
• 18202-73-8 pivalamidine hydrochloride 
• 91167-21-4 5-chloro-2-(1,1-dimethylethyl)pyrimidine 
• 61319-99-1 2-tert-butylpyrimidine 
• 59950-56-0 pivalimidamide 

Downstream Products

• 140201-04-3 2-t-butyl-4-methoxypyrimidine 
• 140201-05-4 2-t-butyl-3-methylpyrimidin-4(3H)-one 
• 70227-50-8 4-chloro-5-nitro-2-t-butylpyrimidine 
• 112381-83-6 1-benzylideneamino-5-t-butyl-1H-v-triazolo<4,5-d>pyrimidine 
• 112381-85-8 4-benzylidenehydrazino-5-nitro-2-t-butylpyrimidine 
• 112381-86-9 5-benzylideneamino-4-benzylidenehydrazino-2-t-butylpyrimidine 
• 70227-51-9 4-amino-5-nitro-2-t-butylpyrimidine 

Relevant articles and documents

Heterocyclic Compounds Useful as RAF Kinase Inhibitors

The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.

PYRIDO PYRIMIDINONES, DIHYDRO PYRIMIDO PYRIMIDINONES AND PTERIDINONES USEFUL AS RAF KINASE INHIBITORS

The present invention provides compounds having the formula: (I) wherein A-B together represents one of the following structures; (II), (III), (IV) and n, R1, R2, R3, R4, L1, L2, Y and Z are as defined in classes and subclasses herein, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful as inhibitors of protein kinase (e.g., RAF), and thus are useful, for example, for the treatment of RAF mediated diseases.

Synthesis of 1- and 3-Amino-5-t-butyl-1H- and -3H-v-triazolopyrimidines as Hetaryne Precursors

The synthesis of the title compounds 6 and 8 has first been accomplished by reaction of O-mesitylsulfonylhydroxylamine with 5-t-butyl-3H-v-triazolopyrimidine (5) whose preparation is reported in detail.However the preferred route for the synthesis