42856-43-9

Basic information

• Product Name: N-Benzyl-2,6-piperidinedion
• Synonyms: 1-Benzyl-2,6-piperidinedione;N-(Phenylmethyl)-2,6-piperidinedion;N-Benzyl-2,6-piperidinedion;N-benzyl-2,6-piperidinedione;1-Benzylpiperidine-2,6-dione
• CAS NO: 42856-43-9
• Molecular Formula: C₁₂H₁₃NO₂
• Molecular Weight: 203.24
• Mol File: 42856-43-9.mol
• Article Data: 22

Chemical Properties

• Melting Point: 48-49 °C
• Boiling Point: 404.6 °C at 760 mmHg
• Flash Point: 195.2 °C
• Appearance: /
• Density: 1.203
• Vapor Pressure: 9.33E-07mmHg at 25°C
• Refractive Index: 1.578
• CAS DataBase Reference: N-Benzyl-2,6-piperidinedion(CAS DataBase Reference)
• NIST Chemistry Reference: N-Benzyl-2,6-piperidinedion(42856-43-9)
• EPA Substance Registry System: N-Benzyl-2,6-piperidinedion(42856-43-9)

Safety Data

• Hazardous Substances Data: 42856-43-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H13NO2/c14-11-7-4-8-12(15)13(11)9-10-5-2-1-3-6-10/h1-3,5-6H,4,7-9H2

Upstream product

• 2873-74-7 gloutaric dichloride 
• 52826-45-6 (benzylimino)triphenylphosphorane 
• 42856-45-1 5-oxo-5-[(phenylmethyl)amino]pentanoic acid 
• 108-55-4 glutaric anhydride, 
• 100-46-9 benzylamine 
• 1121-89-7 piperidine-2,6-dione 
• 100-39-0 benzyl bromide 
• 622-79-7 benzyl azide 
• 111-29-5 1 ,5-pentanediol 
• 1501-26-4 methyl 4-(chlorocarbonyl)butyrate 
• 3424-60-0 pentanediamide 

Downstream Products

• 117416-11-2 1-benzyl-6-methoxy-2-piperidinone 
• 88995-99-7 1-benzyl-6-ethoxy-2-piperidone 
• 88460-82-6 1-benzyl-6-hydroxypiperidin-2-one 
• 108046-33-9 1-benzyl-1,2,3,4-tetrahydro-2-pyridinone 
• 42856-59-7 5-hydroxy-N-(phenylmethyl)-pentanamide 
• 933803-10-2 1-benzyl-6-phenylpiperidin-2-one 
• 933803-11-3 1,6-dibenzyl-piperidin-2-one 
• 933803-07-7 1,6-dibenzyl-3,4-dihydro-1H-pyridin-2-one 
• 933803-12-4 1-benzyl-6-phenethyl-piperidin-2-one 
• 933803-08-8 1-benzyl-6-phenethyl-3,4-dihydro-1H-pyridin-2-one 
• 107520-59-2 N-Benzyl-5,6-dihydro-6-phenyl-2(1H)-pyridinone 
• 41267-62-3 1-benzyl-6-phenyl-3,4-dihydropyridin-2(1H)-one 

Relevant articles and documents

A Unified Strategy for the Synthesis of Difluoromethyl- And Vinylfluoride-Containing Scaffolds

Here, we report a general method for the synthesis of quaternary and tertiary difluoromethylated compounds and their vinylfluoride analogues. The strategy, which relies on a two-step sequence featuring a C-selective electrophilic difluoromethylation and either a palladium-catalyzed decarboxylative protonation or a Krapcho decarboxylation, is practical, scalable, and high yielding. Considering the generality of the method and the attractive properties offered by the difluoromethyl group, this approach provides a valuable tool for late-stage functionalization and drug development.

Highly Enantioselective, Base-Free Synthesis of α-Quaternary Succinimides through Catalytic Asymmetric Allylic Alkylation

The synthesis of diversely substituted five-membered ring succinimide derivatives is reported featuring a direct, base-free, palladium-catalyzed asymmetric allylic alkylation. The method allows a straightforward access to the desired heterocyclic scaffold bearing an all-carbon α-quaternary stereogenic center in high yields and good to excellent enantioselectivities. To further demonstrate the synthetic utility of the method, the allylated products were further converted to various versatile chiral building blocks, including a chiral pyrrolidine and a spirocyclic derivative, using selective transformations.

MANGANESE BASED COMPLEXES AND USES THEREOF FOR HOMOGENEOUS CATALYSIS

The present invention relates to novel manganese complexes and their use, inter alia, for homogeneous catalysis in (1) the preparation of imine by dehydrogenative coupling of an alcohol and amine; (2) C-C coupling in Michael addition reaction using nitriles as Michael donors; (3) dehydrogenative coupling of alcohols to give esters and hydrogen gas (4) hydrogenation of esters to form alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di- lactones), or polyesters); (5) hydrogenation of amides (including cyclic dipeptides, lactams, diamide, polypeptides and polyamides) to alcohols and amines (or diamine); (6) hydrogenation of organic carbonates (including polycarbonates) to alcohols or hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (7) dehydrogenation of secondary alcohols to ketones; (8) amidation of esters (i.e., synthesis of amides from esters and amines); (9) acylation of alcohols using esters; (10) coupling of alcohols with water and a base to form carboxylic acids; and (11) preparation of amino acids or their salts by coupling of amino alcohols with water and a base. (12) preparation of amides (including formamides, cyclic dipeptides, diamide, lactams, polypeptides and polyamides) by dehydrogenative coupling of alcohols and amines; (13) preparation of imides from diols.