4472-73-5Relevant articles and documents
FOUR 6-HYDROXYFLAVONOLS FROM BLUMEA MALCOLMII
Kulkarni, Mandakini M.,Rojatkar, Supada R.,Nagasampagi, Bhimsen A.
, p. 2079 - 2084 (1987)
Four new 6-hydroxyflavonols have been isolated from Blumea malcolmii and identified as 6-hydroxy-3,5,7,4'-tetramethoxyflavone, 6,2',5'-trihydroxy-3,5,7-trimethoxyflavone, 6,5'-dihydroxy-3,5,7,2'-tetramethoxyflavone and 6-hydroxy-3,5,7,2',5'-pentamethoxyfl
ANTIMICROBIAL FLAVONOIDS FROM PSIADIA TRINERVIA AND THEIR METHYLATED AND ACETYLATED DERIVATIVES
Wang, Ying,Hamburger, Matthias,Gueho, Joseph,Hostettmann, Kurt
, p. 2323 - 2328 (2007/10/02)
Key Word Index - Psiadia trinervia; Compositae; flavonoids; antifungal; antibacterial; Cladosporium cucumerinum; Bacillus cereus; bioautography.Abstract - From a dichloromethane extract and a hydrolysed methanolic extract from the leaves of Psiadia trinervia, 13 3-methylated flavonol have beeen isolated.Their structures were established by the usual spectoscopic methods (UV, EIMS, 1H and 13CNMR).Ayanin, casticin, chrysosplenol-D and 5,7,4'-trihydroxy-3,8-dimethoxyflavone were responsible for the antifungal activity found in the preliminary screening.Chrysosplenol-D, isokaemferide, 5,7,4'-trihydroxy-3,3'-dimethoxyflavone and 5,7,4'-trihydroxy-3,8-dimethoxyflavone displayed antibacterial activity.Twenty-nine derivatives were prepared by permethylation and selective methylation of the free hydroxyl group at C-5.The antimicrobial activities of the isolates and derivatives were determined by bioautographic assays using C. cucumerinum and B. cereus as test organisms.