449-46-7

Basic information

• Product Name: Quinoxaline, 2-(4-fluorophenyl)-
• CAS NO: 449-46-7
• Molecular Formula: C14H9FN2
• Molecular Weight: 224.237
• Mol File: 449-46-7.mol
• Article Data: 44

Chemical Properties

• CAS DataBase Reference: Quinoxaline, 2-(4-fluorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinoxaline, 2-(4-fluorophenyl)-(449-46-7)
• EPA Substance Registry System: Quinoxaline, 2-(4-fluorophenyl)-(449-46-7)

Safety Data

• Hazardous Substances Data: 449-46-7(Hazardous Substances Data)

Upstream product

• 17951-22-3 1-(4-fluorophenyl)ethane-1,2-diol 
• 95-54-5 1,2-diamino-benzene 
• 403-31-6 4-fluoro-2-hydroxy-acetophenone 
• 1736-67-0 4-fluorophenylacetaldehyde 
• 1434751-81-1 C₂₃H₁₅FO₃ 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 1128-10-5 1,2-dicarbomethoxycyclobutene 
• 131225-84-8 2-(4-Fluoro-phenyl)-1-phenyl-1,1a-dihydro-3,7b-diaza-cyclopropa[a]naphthalene 
• 53631-18-8 2-bromo-1-(3-fluorophenyl)ethanone 
• 1374152-38-1 1-(1-azidovinyl)-4-fluorobenzene 
• 615-43-0 2-iodophenylamine 
• 403-43-0 4-fluorobenzoyl chloride 
• 91-19-0 2,3-diethynylquinoxaline 
• 371-40-4 4-fluoroaniline 

Downstream Products

• 1287795-36-1 (R)-2-(4-fluorophenyl)-1,2,3,4-tetrahydroquinoxaline 
• 1252876-00-8 (S)-2-(4-fluorophenyl)-1,2,3,4-tetrahydroquinoxaline 
• 930781-41-2 2-(2,4-difluorophenyl)quinoxaline 
• 1444302-13-9 2-(2-fluorophenyl)quinoxaline 
• 1420295-62-0 2-(dimethoxymethyl)-3-(4-fluorophenyl)quinoxaline 
• 1327154-12-0 2-(4-fluorophenyl)-1,2,3,4-tetrahydroquinoxaline 
• 1262801-91-1 2-(4-fluoro-2-nitrophenyl)quinoxaline 

Relevant articles and documents

A quantum-chemical approach to develop tetrahydroquinoxaline as potent ferroptosis inhibitors

Ferroptosis is a recently characterized form of regulated necrosis with the iron-dependent accumulation of (phospho)lipid hydroperoxides (LOOH). It has attracted considerable attention for its putative involvement in diverse pathophysiological processes, such as cardiovascular disease and neurodegeneration. Here we describe the discovery of tetrahydroquinoxaline, a novel scaffold of ferroptosis inhibitors based on quantum chemistry methods. Tetrahydroquinoxaline deviates showed very good inhibition of ferroptosis, while being non cytotoxic for human cancer cells. And, the advantage of them is their small molecular weight (MW. = 148 Da) that can be coupled with other drugs to form multi-target drugs to better meet the treatment of complicated diseases.

A heterogeneous catalytic strategy for facile production of benzimidazoles and quinoxalines from primary amines using the Al-MCM-41 catalyst

This study reports a straightforward heterogeneous catalytic (Al-MCM-41) approach to synthesize nitrogen heterocycle moieties from primary amines under solvent-free conditions. The Al-MCM-41 catalyst was prepared using a hydrothermal method and characterized by various analytical techniques. The probability and limitations of the catalytic methodology were presented with various substrates. The catalytic method grants an attractive route to a wide variety of benzimidazole and quinoxaline moieties with good to excellent yields. The gram scale reaction and reusability (up to five cycles) of the Al-MCM-41 catalyst would greatly benefit industrial applications. This journal is

Bonded- A nd discreted-Lindqvist hexatungstate-based copper hybrids as heterogeneous catalysts for the one-pot synthesis of 2-phenylquinoxalines: Via 2-haloanilines with vinyl azides or 3-phenyl-2 H-azirines

One bonded- A nd one discreted-Lindqvist hexatungstate-based copper hybrids (Cu-POMs) ([Cu2(O)OH (phen)2]2[W6O19]?6H2O (1) and [Cu2(phen)4Cl] [HW6O19]?2H2O (2) (phen = 1,10-phenanthroline)) were controllably synthesized and routinely characterized. Cu-POM