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454464-38-1

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454464-38-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 454464-38-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,5,4,4,6 and 4 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 454464-38:
(8*4)+(7*5)+(6*4)+(5*4)+(4*6)+(3*4)+(2*3)+(1*8)=161
161 % 10 = 1
So 454464-38-1 is a valid CAS Registry Number.

454464-38-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(chloromethyl)-4-[4-(trifluoromethyl)phenyl]benzene

1.2 Other means of identification

Product number -
Other names 4-Chloromethyl-4'-trifluoromethyl-biphenyl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:454464-38-1 SDS

454464-38-1Relevant articles and documents

RADIOLABELED DARAPLADIB AND ANALOGS THEREOF AND THEIR USE AS IMAGING COMPOUNDS

-

, (2019/04/26)

The present inventors have developed new radiolabeled Darapladib and analogs thereof which can be used for the specific detection of vulnerable atherosclerotic plaques by targeting lipoprotein-associated phospholipase A2 (Lp-PLA2) which is a biomarker of

Synthesis and evaluation of an orally available “Y”-shaped biaryl peroxisome proliferator-activated receptor δ agonist

Kim, Dong-Su,Lee, Jaehwan,Londhe, Ashwini M.,Kadayat, Tara Man,Joo, Jeongmin,Hwang, Hayoung,Kim, Kyung-Hee,Pae, Ae Nim,Chin, Jungwook,Cho, Sung Jin,Kang, Heonjoong

, p. 4382 - 4389 (2018/07/30)

In this study, we designed and synthesized several novel “Y”-shaped biaryl PPARδ agonists. Structure-activity relationship (SAR) studies demonstrated that compound 3a was the most active agonist with an EC50 of 2.6 nM. We also synthesized and evaluated enantiospecific R and S isomers of compound 3a to confirm that R isomer (EC50 = 0.7 nM) shows much more potent activity than S isomer (EC50 = 6.1 nM). Molecular docking studies between the PPAR ligand binding domain and enantiospecific R and S isomers of compound 3a were performed. In vitro absorption, distribution, metabolism, excretion, and toxicity (ADMET) and in vivo PK profiles show that compound 3a possesses superior drug-like properties including good bioavailability. Our overall results clearly demonstrate that this orally administrable PPARδ agonist 3a is a viable drug candidate for the treatment of various PPARδ-related disorders.

Tetrazole Derivatives and Their Use for the Treatment of Cardiovascular Diseases

-

, (2009/09/07)

The present application relates to novel tetrazole derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especial

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