4546-48-9

Basic information

• Product Name: 2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID METHYL ESTER
• Synonyms: 2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID METHYL ESTER;METHYL 2-PHENYL-4-QUINOLINECARBOXYLATE
• CAS NO: 4546-48-9
• Molecular Formula: C₁₇H₁₃NO₂
• Molecular Weight: 263.29
• Product Categories: API intermediates;Building Blocks;Heterocyclic Building Blocks;Quinolines
• Mol File: 4546-48-9.mol
• Article Data: 23

Chemical Properties

• Melting Point: 60-62 °C(lit.)
• Boiling Point: 430.8°C at 760 mmHg
• Flash Point: 214.4°C
• Appearance: /
• Density: 1.197g/cm³
• Vapor Pressure: 1.26E-07mmHg at 25°C
• Refractive Index: 1.632
• CAS DataBase Reference: 2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID METHYL ESTER(4546-48-9)
• EPA Substance Registry System: 2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID METHYL ESTER(4546-48-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 4546-48-9(Hazardous Substances Data)

Usage

General Description

2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID METHYL ESTER is a chemical compound that belongs to the quinoline class of organic molecules. It is a methyl ester derivative of 2-phenyl-quinoline-4-carboxylic acid, which is commonly used as a building block in the synthesis of various pharmaceuticals and fine chemicals. 2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID METHYL ESTER has potential applications in the field of drug discovery and medicinal chemistry due to its structural versatility and ability to interact with biological targets. Additionally, 2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID METHYL ESTER may also be utilized as a fluorescent probe or as an intermediate in the production of other functionalized quinoline derivatives.

InChI:InChI=1/C17H13NO2/c1-20-17(19)14-11-16(12-7-3-2-4-8-12)18-15-10-6-5-9-13(14)15/h2-11H,1H3

Upstream product

• 132-60-5 cinchophen 
• 67-56-1 methanol 
• 59661-86-8 2-phenylquinoline-4-carbonyl chloride 
• 65417-19-8 methyl 2-phenylquinoline-4-carboxylate 1-oxide 
• 107-18-6 allyl alcohol 
• 292638-85-8 acrylic acid methyl ester 
• 1750-36-3 (E)-N-benzylidenebenzenamine 
• 74-88-4 methyl iodide 
• 600-22-6 pyruvic acid methyl ester 
• 4519-46-4 methyl 2-bromoacrylate 
• 36997-05-4 2-methoxyacrylic acid ethyl ester 
• 100-52-7 benzaldehyde 
• 62-53-3 aniline 
• 758640-21-0 N-Benzylaniline 

Downstream Products

• 855167-11-2 2-phenyl-quinoline-4-carboxylic acid-(2-benzo[1,3]dioxol-5-yl-ethylamide) 
• 29268-33-5 4-hydroxymethyl-2-phenylquinoline 
• 5855-52-7 2-phenylquinolin-4-amine 
• 838828-67-4 2-(2-phenyl-[4]quinolyl)-propan-2-ol 
• 838828-68-5 2-isopropenyl-2-phenylquinoline 
• 854386-52-0 5-(2-phenyl-[4]quinolyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline 
• 80221-48-3 2-[3(R)-ethenyl-4(S)-piperidyl]-1-(2-phenyl-4-quinolyl) ethanone 
• 1415314-26-9 1,1,1,3,3,3-hexafluoro-2(2-phenylquinolin-4-yl)propan-2-ol 

Relevant articles and documents

Synthesis of substituted quinolines via B(C6F5)3-catalyzed aniline-aldehyde-pyruvate oxidative annulation

A metal-free method to construct quinoline derivatives via B(C6F5)3-catalyzed cyclization of anilines with aldehyde derivatives and pyruvates is described. This three-component cascade reaction provides an efficient approa

The remarkable selectivity of the 2-arylquinoline-based acyl hydrazones toward copper salts: Exploration of their catalytic applications in the copper catalysed: N -arylation of indole derivatives and C1-alkynylation of tetrahydroisoquinolines via the A

Ligands promoting copper-catalysed coupling reactions have received increasing attention because of their ability to enhance the catalytic activity of copper, making these reactions applicable in different fields such as drugs, pharmaceutically interestin

Selective Methylation of Arenes: A Radical C?H Functionalization/Cross-Coupling Sequence

A selective, nonchelation-assisted methylation of arenes has been developed. The overall transformation, which combines a C?H functionalization reaction with a nickel-catalyzed cross-coupling, offers rapid access to methylated arenes with high para selectivity. The reaction is amenable to late-stage methylation of small-molecule pharmaceuticals.