471905-61-0 Usage
Type of compound
Novel and potent transient receptor potential melastatin 8 (TRPM8) antagonist
Function
Modulation of TRPM8, a cold and menthol receptor
Therapeutic applications
Potential use in pain and neurogenic inflammation
In vitro effectiveness
Effectively blocks TRPM8-mediated calcium influx
In vivo effectiveness
Reduces inflammatory and neuropathic pain in animal models
Potential implications
Treatment of conditions such as arthritis and neuropathic pain as a novel analgesic and anti-inflammatory agent.
Check Digit Verification of cas no
The CAS Registry Mumber 471905-61-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,1,9,0 and 5 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 471905-61:
(8*4)+(7*7)+(6*1)+(5*9)+(4*0)+(3*5)+(2*6)+(1*1)=160
160 % 10 = 0
So 471905-61-0 is a valid CAS Registry Number.
471905-61-0Relevant articles and documents
A practical synthesis of a γ-secretase inhibitor
Scott, Jeremy P.,Lieberman, David R.,Beureux, Olivier M.,Brands, Karel M. J.,Davies, Antony J.,Gibson, Andrew W.,Hammond, Deborah C.,McWilliams, Chris J.,Stewart, Gavin W.,Wilson, Robert D.,Dolling, Ulf-H.
, p. 4149 - 4155 (2008/02/05)
(Chemical Equation Presented) A practical and scaleable synthesis of the γ-secretase inhibitor 1 is reported. The inhibitor consists of a central trisubstituted cyclohexane core with appended propionic acid, 2,5-difluorophenyl, and 4-chlorophenylsulfonyl