656810-84-3

Basic information

• Product Name: 2-(4-(4-chlorophenylsulfonyl)-4-(2,5-difluorophenyl)cyclohexylidene)acetonitrile
• Synonyms: 2-(4-(4-chlorophenylsulfonyl)-4-(2,5-difluorophenyl)cyclohexylidene)acetonitrile
• CAS NO: 656810-84-3
• Molecular Formula: C₂₀H₁₆ClF₂NO₂S
• Molecular Weight: 407.8613464
• Mol File: 656810-84-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 586.7±50.0 °C(Predicted)
• Appearance: /
• Density: 1.419±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-(4-(4-chlorophenylsulfonyl)-4-(2,5-difluorophenyl)cyclohexylidene)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-(4-chlorophenylsulfonyl)-4-(2,5-difluorophenyl)cyclohexylidene)acetonitrile(656810-84-3)
• EPA Substance Registry System: 2-(4-(4-chlorophenylsulfonyl)-4-(2,5-difluorophenyl)cyclohexylidene)acetonitrile(656810-84-3)

Safety Data

• Hazardous Substances Data: 656810-84-3(Hazardous Substances Data)

Upstream product

• 471903-20-5 4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanone 
• 2537-48-6 diethyl 1-cyanomethylphosphonate 
• 470716-52-0 2-[[(4-chlorophenyl)thio]methyl]-1,4-difluorobenzene 
• 470716-51-9 2-[[(4-chlorophenyl)sulfonyl]methyl]-1,4-difluorobenzene 
• 471905-61-0 2-[1-[(4-chlorophenyl)sulfonyl]ethenyl]-1,4-difluorobenzene 
• 106-54-7 p-Chlorothiophenol 
• 85117-99-3 2-(bromomethyl)-1,4-difluorobenzene 
• 865-47-4 potassium tert-butylate 

Downstream Products

• 471905-01-8 cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexylacetonitrile 
• 656810-85-4 cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexylacetaldehyde 
• 656810-86-5 cis-1-[4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-3-propanal 
• 471905-41-6 3-((1S,4R)-4-((4-chlorophenyl)sulfonyl)-4-(2,5- difluorophenyl)cyclohexyl)propanoic acid 

Relevant articles and documents

A practical synthesis of a γ-secretase inhibitor

(Chemical Equation Presented) A practical and scaleable synthesis of the γ-secretase inhibitor 1 is reported. The inhibitor consists of a central trisubstituted cyclohexane core with appended propionic acid, 2,5-difluorophenyl, and 4-chlorophenylsulfonyl

Novel cyclohexyl sulphones

Novel sulphones of formula I are disclosed: The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.