4904-83-0

Basic information

• Product Name: 5,11-dihydro-5-methyl-10H-dibenz[b,f]azepin-10-one
• Synonyms: 5,11-dihydro-5-methyl-10H-dibenz[b,f]azepin-10-one;5-Methyl-5H-dibenzo[b,f]azepine-10(11H)-one;Einecs 225-534-3
• CAS NO: 4904-83-0
• Molecular Formula: C₁₅H₁₃NO
• Molecular Weight: 223.26982
• EINECS: 225-534-3
• Mol File: 4904-83-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 387.1°C at 760 mmHg
• Flash Point: 156.5°C
• Appearance: /
• Density: 1.166g/cm³
• Vapor Pressure: 3.37E-06mmHg at 25°C
• Refractive Index: 1.615
• Solubility: DCM, DMSO, Ethyl Acetate
• CAS DataBase Reference: 5,11-dihydro-5-methyl-10H-dibenz[b,f]azepin-10-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5,11-dihydro-5-methyl-10H-dibenz[b,f]azepin-10-one(4904-83-0)
• EPA Substance Registry System: 5,11-dihydro-5-methyl-10H-dibenz[b,f]azepin-10-one(4904-83-0)

Safety Data

• Hazardous Substances Data: 4904-83-0(Hazardous Substances Data)

Usage

Description

5,11-dihydro-5-methyl-10H-dibenz[b,f]azepin-10-one is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceuticals. It is characterized by its unique chemical structure, which includes a dibenzazepinone core with a methyl group and a hydrogenated ring system. 5,11-dihydro-5-methyl-10H-dibenz[b,f]azepin-10-one plays a significant role in the development of medications targeting specific neurotransmitter systems.

Uses

Used in Pharmaceutical Industry:
5,11-dihydro-5-methyl-10H-dibenz[b,f]azepin-10-one is used as a key intermediate in the synthesis of Metapramine (M225830), a norepinephrine reuptake inhibitor. It is specifically designed to inhibit the reuptake of norepinephrine without affecting the reuptake of serotonin or dopamine, making it a valuable compound for the development of medications to treat conditions related to the imbalance of these neurotransmitters, such as attention deficit hyperactivity disorder (ADHD) and certain mood disorders.

InChI:InChI=1/C15H13NO/c1-16-13-8-4-2-6-11(13)10-15(17)12-7-3-5-9-14(12)16/h2-9H,10H2,1H3

Upstream product

• 207802-82-2 N,N-diethyl-2-(2,N-dimethylanilino)benzamide 
• 5003-62-3 10-methoxy-5-methyl-5H-dibenzo[b,f]azepine 
• 1093239-41-8 N,N-dimethyl-2-(2,N-dimethylanilino)benzamide 
• 1093239-43-0 N,N-diisopropyl-2-(2,N-dimethylanilino)benzamide 
• 50777-64-5 2-(2-bromophenyl)-2-methyl-1,3-dioxolane 
• 1352449-00-3 2-chloro-N-(2-(2-methyl-1,3-dioxolan-2-yl)phenyl)aniline 
• 1352449-01-4 N-methyl-N-(2-chlorophenyl)-2'-aminoacetophenone 
• 95-51-2 o-chloroaniline 
• 4217-54-3 9,10-dihydro-10-methylacridine 
• 719-54-0 10-methyl-9, 10-dihydro-9-acridinone 
• 52249-32-8 N-methyldibenzazepine 
• 578-95-0 10H-acridin-9-one 
• 28291-62-5 5-methyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10-ol 
• 88975-25-1 2-(2-(methylamino)phenyl)acetonitrile 

Downstream Products

• 52813-96-4 [2-(8-Ethanesulfonyl-5-methyl-5H-dibenzo[b,f]azepin-10-yl)-ethyl]-methyl-amine 
• 52813-87-3 ethylthio-8 methyl-5 5H-dibenzazepine-10-acetate de nitro-4 phenyle 
• 84142-00-7 methyl-4 benzene sulfonate de chloro-8 methyl-5 5H-dibenzazepine-10-ethanol 
• 28941-77-7 Dimethyl-(5-methyl-5H-dibenzo[b,f]azepin-10-ylmethyl)-amine; hydrochloride 
• 84142-01-8 chloro-8 methyl-5 5H-dibenzylazepine-10-ethanamine 
• 52249-32-8 N-methyldibenzazepine 

Relevant articles and documents

Intermediate compound, carbamazepine and derivative thereof as well as preparation method of oxcarbazepine and derivative thereof

The invention provides an intermediate compound, carbamazepine and a derivative thereof as well as a preparation method of oxcarbazepine and a derivative thereof. 2-substituted aminophenylacetate or 2-substituted aminophenylacetonitrile and 2-halobenzonitrile are used as raw materials, substitution reaction, intramolecular condensation reaction, hydrolysis and hydrochloric acid acidification are carried out to obtain the oxcarbazepine and the derivative 5-substituent-10-oxa-10, 11-dihydro-5H-dibenzo [b, f] aza thereof, and the derivative of the oxcarbazepine can be used as a raw material to prepare the carbamazepine and the derivative 5-substituted iminostilbene thereof, an intermediate compound iminostilbene and intermediate compounds 5-substituted-10-methoxyiminostilbene and 10-methoxyiminostilbene. The raw materials used in the method are cheap and easy to obtain, and the cost is low; the preparation method is simple, conditions are easy to realize, the method is simple, convenientand safe to operate, and the process flow is short; the production amount of three wastes is small, and thus, the method is environmentally friendly; and a target product has high yield and purity, and is suitable for industrial production.

Synthesis of benzo-fused heterocycles by intramolecular α-arylation of ketone enolate anions

A two-step synthesis of six-, seven-, eight-, and nine-member benzo-fused heterocycles in good to excellent yields is reported. The synthetic strategy involves the generation of a new intramolecular α-aryl ketone bond by the photostimulated SRN1 reaction of ketone enolate anions linked to a pendant haloarene as the key step. On the other hand, an intramolecular C Ar-CAr coupling led to the formation of five- and six-member benzo-fused heterocycles (9H-carbazole and phenanthridine) when an aromatic amide anion is competitively formed.

N-substituted azaheterocyclic carboxylic acids and alkylesters thereof

The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.