52249-32-8

Basic information

• Product Name: 5-Methyl-5H-dibenz[b,f]azepine
• Synonyms: 5-Methyl-5H-dibenz[b,f]azepine
• CAS NO: 52249-32-8
• Molecular Formula: C₁₅H₁₃N
• Molecular Weight: 207.2704
• Mol File: 52249-32-8.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 341.7°Cat760mmHg
• Flash Point: 145.4°C
• Appearance: /
• Density: 1.101g/cm³
• Vapor Pressure: 7.91E-05mmHg at 25°C
• Refractive Index: 1.622
• Solubility: DCM, Toluene
• CAS DataBase Reference: 5-Methyl-5H-dibenz[b,f]azepine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methyl-5H-dibenz[b,f]azepine(52249-32-8)
• EPA Substance Registry System: 5-Methyl-5H-dibenz[b,f]azepine(52249-32-8)

Safety Data

• Hazardous Substances Data: 52249-32-8(Hazardous Substances Data)

Usage

Description

5-Methyl-5H-dibenz[b,f]azepine is a chemical compound belonging to the class of azepines, which are part of the larger group of nitrogen-containing heterocycles. It is characterized by its fused benzene rings and a nitrogen atom in the ring structure, with an additional methyl group attached. 5-Methyl-5H-dibenz[b,f]azepine has potential applications in various fields due to its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
5-Methyl-5H-dibenz[b,f]azepine is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a key component in the development of new drugs targeting specific receptors or enzymes in the body.
Used in Metabolite Research:
5-Methyl-5H-dibenz[b,f]azepine is found as a metabolite of Metapramine (M225830) in the plasma of depressed inpatients. This application is significant for understanding the metabolic pathways of certain drugs and their effects on patients, which can help in the development of more effective treatments for depression and other related conditions.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 24, p. 2751, 1976 DOI: 10.1248/cpb.24.2751

InChI:InChI=1/C15H13N/c1-16-14-8-4-2-6-12(14)10-11-13-7-3-5-9-15(13)16/h2-11H,1H3

Upstream product

• 67630-05-1 5-methyl-10,11-dihydro-5H-dibenzo[b,f]azepine-10-carboxylic acid 
• 256-96-2 dibenzoazepine 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 5336-90-3 acridine-9-carboxylic acid 
• 66074-67-7 9-acridinecarbonyl chloride 
• 5132-81-0 methyl acridine-9-carboxylate 
• 5132-82-1 9-[(carbonyl)methoxy]-10-methylacridinium methylsulfate 
• 153562-07-3 9-ethoxycarbonyl-10-methylacridane 
• 153562-09-5 5-Methyl-10,11-dihydro-5H-dibenzo[b,f]azepine-10-carboxylic acid ethyl ester 
• 153562-08-4 9-Bromomethyl-10-methyl-9,10-dihydro-acridine-9-carboxylic acid ethyl ester 
• 1427210-31-8 N,N-bis(2-vinylphenyl)methylamine 
• 1427210-35-2 N,N-bis(2-formylphenyl)methylamine 
• 19493-09-5 Methylenetriphenylphosphorane 

Downstream Products

• 4513-01-3 10,11-dihydro-5-methyl-5H-dibenz[b,f]azepine 
• 256-96-2 dibenzoazepine 
• 719-54-0 10-methyl-9, 10-dihydro-9-acridinone 
• 78943-66-5 N-methyldibenzazepine-N-oxide 
• 78943-65-4 N-methyl-2-formyl-2'-hydroxydiphenylamine 
• 117600-92-7 (3aR,12bR)-8-Methyl-1,3-diphenyl-1,3a,8,12b-tetrahydro-1,2,8-triaza-dibenzo[e,h]azulene 
• 117600-94-9 (3aR,12bR)-8-Methyl-1-phenyl-1,3a,8,12b-tetrahydro-1,2,8-triaza-dibenzo[e,h]azulene-3-carboxylic acid ethyl ester 
• 4904-83-0 5-methyl-10-oxo-10,11-dihydro-5H-dibenzo[b,f]azepine 

Relevant articles and documents

Broadening the Horizon of the Bell–Evans–Polanyi Principle towards Optically Triggered Structure Planarization

Finding a relationship between kinetics and thermodynamics may be difficult. However, semi-empirical rules exist to compensate for this shortcoming, among which the Bell–Evans–Polanyi (B-E-P) principle is an example for reactions involving bond breakage a

Azepine- or Azocine-Embedded Hexabenzocoronene Derivatives as Nitrogen-Doped Saddle or Saddle-Helix Nanographenes

Two novel nitrogen-doped, hexa-peri-hexabenzocoronene (HBC)-based nanographenes (NGs) 1 and 2 bearing an azepine and an azocine at the fjord region, respectively, were synthesized and characterized. Notably, structure 1 was synthesized by Diels–Alder reac

Preparation method of N-methylamine compound

The invention discloses a preparation method of a N-methylamine compound. The preparation method comprises the following steps: under an inertia organic solvent or solvent-free condition and under a support-type nano-sized gold catalyst effect, a primary amine compound or a secondary amine compound is subjected to a N-methylation reaction with carbon dioxide and hydrogen to obtain the product. The preparation method takes CO2 as a methyl source, takes hydrogen as a reducing agent, and takes the support-type nano-gold as a catalyst, and has the advantages that process is simple, catalyst activity is high, reaction rate is fast, the catalyst recovery and utilization are convenient, the application scope of a substrate is wide, the production cost is low, the benifit is high, the post-treatment is simple, repeatability is good, safe performance is high, and environmental protection is achieved, and the method is adapted to industrial production.