4937-62-6

Basic information

• Product Name: 2-AMINO-4-METHYLBENZOPHENONE
• Synonyms: 2-AMINO-4-METHYLBENZOPHENONE;(2-amino-4-methyl-phenyl)-phenyl-methanone;(2-amino-4-methylphenyl)-phenylmethanone;(2-azanyl-4-methyl-phenyl)-phenyl-methanone
• CAS NO: 4937-62-6
• Molecular Formula: C₁₄H₁₃NO
• Molecular Weight: 211.26
• EINECS: 225-577-8
• Product Categories: C13 to C14;Carbonyl Compounds;Ketones
• Mol File: 4937-62-6.mol
• Article Data: 17

Chemical Properties

• Melting Point: 65-66 °C(lit.)
• Boiling Point: 407.1°C at 760 mmHg
• Flash Point: 200°C
• Appearance: /
• Density: 1.135g/cm³
• Vapor Pressure: 7.75E-07mmHg at 25°C
• Refractive Index: 1.616
• CAS DataBase Reference: 2-AMINO-4-METHYLBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4-METHYLBENZOPHENONE(4937-62-6)
• EPA Substance Registry System: 2-AMINO-4-METHYLBENZOPHENONE(4937-62-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 4937-62-6(Hazardous Substances Data)

Usage

Description

2-Amino-4-methylbenzophenone is an organic compound with the molecular formula C14H13NO. It is a derivative of benzophenone, featuring an amino group at the 2nd position and a methyl group at the 4th position on the benzene ring. 2-Amino-4-methylbenzophenone is known for its chemical reactivity and is often utilized as a starting material in the synthesis of various complex organic molecules.

Uses

Used in Pharmaceutical Industry:
2-Amino-4-methylbenzophenone is used as a starting reagent for the synthesis of complex organic molecules with potential pharmaceutical applications. Its unique structure allows for the creation of diverse compounds with specific biological activities.
Used in Synthesis of Quinoline Derivatives:
2-Amino-4-methylbenzophenone is used as a starting reagent for the synthesis of 4-phenyl-7-methyl-2-(2′-pyridyl)quinoline and 4-phenyl-7-methyl-2-[2′-(6′-methyl)pyridyl]-quinoline. These quinoline derivatives have potential applications in the development of new drugs due to their diverse biological properties.
Used in Synthesis of Benzazepine Derivatives:
2-Amino-4-methylbenzophenone is also used as a starting reagent in the synthesis of N-tert-butyl-2-3(R)-[3-(3-chlorophenyl)ureido]-8-methyl-2-oxo-5(R)-phenyl-1,3,4,5-tetrahydrobenz[b]azepin-1-ylacetamide. Benzazepine derivatives are known for their potential therapeutic applications, particularly in the treatment of various central nervous system disorders.

InChI:InChI=1/C14H13NO/c1-10-7-8-12(13(15)9-10)14(16)11-5-3-2-4-6-11/h2-9H,15H2,1H3

Upstream product

• 857775-99-6 1-(6-methyl-2,3-diphenyl-1H-indol-1-yl)ethan-1-one 
• 100224-75-7 4-methyl-2-nitro-benzophenone 
• 582-77-4 3'-methylbenzanilide 
• 26830-96-6 5-methyl-2-cyanoaniline 
• 100-47-0 benzonitrile 
• 108-44-1 1-amino-3-methylbenzene 
• 98-88-4 benzoyl chloride 
• 26830-95-5 4-methyl-2-nitrobenzonitrile 
• 89-62-3 4-methyl-2-nitroaniline 
• 54879-92-4 6-methyl-2,3-diphenyl-1H-indole 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 941-55-9 4-toluenesulfonyl azide 
• 134-84-9 4-Methylbenzophenone 
• 873-55-2 sodium benzenesulfonate 

Downstream Products

• 3098-18-8 2-hydroxy-4-methylbenzophenone 
• 1705-89-1 3-methyl-9H-fluoren-9-one 
• 139436-94-5 1-(2'-amino-4'-methylphenyl)-1-phenylprop-2-en-1-ol 
• 149195-56-2 N-(2-Benzoyl-5-methyl-phenyl)-2,2,2-trifluoro-acetamide 
• 91409-75-5 N-(2-benzoyl-5-methylphenyl)alanine ethyl ester 
• 52164-37-1 2-Iod-4-methylbenzophenon 
• 411238-50-1 2-benzyl-5-methylaniline 
• 335305-91-4 2-benzoyl-5-methylphenyl radical 
• 177365-01-4 5-methyl-2-(1-phenylvinyl)aniline 
• 177365-02-5 N-{methoxy-[5-methyl-2-(1-phenyl-vinyl)-phenylcarbamoyl]-methyl}-benzamide 
• 161464-84-2 7-methyl-4-phenyl-3-(1-phenyl-1H-tetrazol-5-yl)quinoline 

Relevant articles and documents

One-Pot Synthesis of 2-Aminobenzophenones from 2-Alkynyl Arylazides Catalyzed by Pd and Cu Precursors

We describe a novel one-pot three-step reaction of 2-alkynyl arylazides through palladium-catalyzed formation of 3-hydroxy-3-phenylindolin-2-ones followed by hydrolysis of amide bonds and copper-catalyzed decarboxylation to give 2-aminobenzophenones. This synthetic method works well with various 2-alkynyl arylazides and affords the products in moderate to good yields under mild reaction conditions.

Visible Light Induced Cyclization to Spirobi[indene] Skeletons from Functionalized Alkylidienecyclopropanes

In this paper, we revealed a metal-free and visible light photoinduced method for the rapid construction of spirobi[indene] skeletons, providing a simple and efficient way for easy access to spirobi[indene] scaffolds under mild conditions along with a broad substrate scope and good functional group tolerance.

Deoxygenative Arylation of Carboxylic Acids by Aryl Migration

An unprecedented deoxygenative arylation of aromatic carboxylic acids has been achieved, allowing the construction of an enhanced library of unsymmetrical diaryl ketones. The synergistic photoredox catalysis and phosphoranyl radical chemistry allows for precise cleavage of a stronger C?O bond and formation of a weaker C?C bond by 1,5-aryl migration under mild reaction conditions. This new protocol is independent of substrate redox-potential, electronic, and substituent effects. It affords a general and promising access to 60 examples of synthetically versatile o-amino and o-hydroxy diaryl ketones under redox-neutral conditions. Furthermore, it also brings one concise route to the total synthesis of quinolone alkaloid, (±)-yaequinolone A2, and a viridicatin derivative in satisfying yields.