49545-70-2

Basic information

• Product Name: 2-(4-chlorobenzylidene)-3,4-dihydronaphthalen-1(2H)-one
• Synonyms: 2-(4-Chlorophenylmethylene)-1-tetralone
• CAS NO: 49545-70-2
• Molecular Formula: C₁₇H₁₃ClO
• Molecular Weight: 268.7375
• Mol File: 49545-70-2.mol
• Article Data: 30

Chemical Properties

• Boiling Point: 431.7°C at 760 mmHg
• Flash Point: 239.7°C
• Density: 1.264g/cm³
• Vapor Pressure: 1.17E-07mmHg at 25°C
• Refractive Index: 1.662
• CAS DataBase Reference: 2-(4-chlorobenzylidene)-3,4-dihydronaphthalen-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorobenzylidene)-3,4-dihydronaphthalen-1(2H)-one(49545-70-2)
• EPA Substance Registry System: 2-(4-chlorobenzylidene)-3,4-dihydronaphthalen-1(2H)-one(49545-70-2)

Safety Data

• Hazardous Substances Data: 49545-70-2(Hazardous Substances Data)

Usage

Molecular Structure

2-(4-chlorobenzylidene)-3,4-dihydronaphthalen-1(2H)-one consists of a complex structure that includes a chlorobenzylidene group (a benzylidene group with a chlorine atom attached to the benzene ring) and a dihydronaphthalenone group (a naphthalenone group with two additional carbon atoms forming a six-membered ring).

Common Uses

This chemical compound is commonly used in the synthesis of pharmaceuticals and agrochemicals.

Potential Applications

2-(4-chlorobenzylidene)-3,4-dihydronaphthalen-1(2H)-one has potential applications as an intermediate for the production of various drugs and agricultural chemicals.

Chemical Reactivity

The compound has a versatile chemical structure and reactivity, making it useful in the synthesis of various products.

Safety Precautions

It is important to handle and use this compound with caution due to its potential for toxic and hazardous properties.

Further Research

More research and development is needed to explore the potential uses and applications of 2-(4-chlorobenzylidene)-3,4-dihydronaphthalen-1(2H)-one in various industries.

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 873-76-7 para-Chlorobenzyl alcohol 

Downstream Products

• 138421-80-4 trans-(+/-)-3,4,4',5'-Tetrahydro-4'-(4-chlorophenyl)-spiropyrazol>-1-one 
• 109329-53-5 3,4-Bis-(4-chloro-phenyl)-3,4,5,6-tetrahydro-1H-benzo[h]quinolin-2-one 
• 97145-64-7 4-(4-chlorophenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine 
• 41814-29-3 3-(4-Chloro-phenyl)-3,3a,4,5-tetrahydro-2H-benzo[g]indazole 
• 129116-55-8 1-(4-Chloro-phenyl)-3-oxo-1,2,3,9,10,10a-hexahydro-phenanthrene-2-carboxylic acid (2-chloro-phenyl)-amide 
• 129078-78-0 1-(4-Chloro-phenyl)-3-oxo-1,2,3,9,10,10a-hexahydro-phenanthrene-2-carboxylic acid (2-nitro-phenyl)-amide 
• 129116-56-9 1-(4-Chloro-phenyl)-3-oxo-1,2,3,9,10,10a-hexahydro-phenanthrene-2-carboxylic acid (4-dimethylamino-phenyl)-amide 
• 128483-26-1 2-Mercapto-4-p-chlorophenyl-4H-1,2,3,4,5,6-hexahydrobenzo-quinazoline 
• 78364-68-8 2-Bromo-2-[bromo-(4-chloro-phenyl)-methyl]-3,4-dihydro-2H-naphthalen-1-one 
• 109329-45-5 4-(4-Chloro-phenyl)-3-phenyl-3,4,5,6-tetrahydro-1H-benzo[h]quinolin-2-one 
• 95015-17-1 4-(4-Chloro-phenyl)-1,4,5,6-tetrahydro-naphtho[1,2-d][1,3]thiazin-2-ylideneamine; hydrochloride 
• 106319-27-1 2-phenyl-4-(4-chlorophenyl)-3,4,5,6-tetrahydrobenzoquinazoline 
• 106319-27-1 4-(4-Chloro-phenyl)-2-phenyl-1,4,5,6-tetrahydro-benzo[h]quinazoline 
• 49545-61-1 3-(4-chlorophenyl)-3,3a,4,5-tetrahydro-2-phenyl-2H-benzo[g]indazole 

Relevant articles and documents

Asymmetric Transfer Hydrogenation of Arylidene-Substituted Chromanones and Tetralones Catalyzed by Noyori-Ikariya Ru(II) Complexes: One-Pot Reduction of C═C and C═O bonds

3-Arylidenechroman-4-ones and 2-arylidene-1-tetralones are hydrogenated to cis-benzylic alcohols in dr's and er's up to 99:1 via a C═C and C═O one-pot reduction in the presence of 2-5 mol % Noyori-Ikariya-type RuII chiral complexes and HCO2Na as a hydroge

I2/TBHP mediated diastereoselective synthesis of spiroaziridines

Eventhough spiroheterocycles are considered as emerging drug candidates, synthesis of spiroaziridines has not been well explored so far. Herein, we disclose an efficient I2/TBHP mediated diastereoselective synthesis of N-alkyl spiroaziridines from primary amines and easily accessible α,β-unsaturated ketones. The reaction is also compatible for the synthesis of 2-aroylaziridines.

A simple iron-catalyst for alkenylation of ketones using primary alcohols

Herein, we developed a simple iron-catalyzed system for the α-alkenylation of ketones using primary alcohols. Such acceptor-less dehydrogenative coupling (ADC) of alcohols resulted in the synthesis of a series of important α,β-unsaturated functionalized ketones, having aryl, heteroaryl, alkyl, nitro, nitrile and trifluoro-methyl, as well as halogen moieties, with excellent yields and selectivity. Initial mechanistic studies, including deuterium labeling experiments, determination of rate and order of the reaction, and quantitative determination of H2 gas, were performed. The overall transformations produce water and dihydrogen as byproducts.