502935-47-9 Usage
Description
2,4-Diphenyl-1,3-thiazole-5-carboxylic acid is an organic compound characterized by its thiazole and carboxylic acid functional groups. It is a key intermediate in the synthesis of various pharmaceutical compounds, particularly those with potential applications in the treatment of cancer and other diseases.
Uses
Used in Pharmaceutical Industry:
2,4-Diphenyl-1,3-thiazole-5-carboxylic acid is used as a key intermediate in the synthesis of FASN (Fatty Acid Synthase) inhibitors for the treatment of cancer and other diseases. These inhibitors target the enzyme responsible for the synthesis of fatty acids, which is often overexpressed in cancer cells, leading to uncontrolled cell growth and proliferation. By inhibiting FASN, these compounds can potentially slow down or stop the growth of cancer cells, making them a valuable tool in the development of novel cancer therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 502935-47-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,0,2,9,3 and 5 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 502935-47:
(8*5)+(7*0)+(6*2)+(5*9)+(4*3)+(3*5)+(2*4)+(1*7)=139
139 % 10 = 9
So 502935-47-9 is a valid CAS Registry Number.
InChI:InChI=1/C16H11NO2S/c18-16(19)14-13(11-7-3-1-4-8-11)17-15(20-14)12-9-5-2-6-10-12/h1-10H,(H,18,19)
502935-47-9Relevant articles and documents
Design, synthesis and RON receptor tyrosine kinase inhibitory activity of new head groups analogs of LCRF-0004
Raeppel, Franck,Raeppel, Stéphane L.,Therrien, Eric
, p. 3810 - 3815 (2015/08/24)
New heteroarylcarboxamide head groups substituted with two aromatic rings analogs of thieno[3,2-b]pyridine-based kinase inhibitor LCRF-0004 were designed and synthesized. Potent inhibitors of RON tyrosine kinase with various level of selectivity for c-Met RTK were obtained.
A general and efficient PIFA mediated synthesis of heterocycle-fused quinolinone derivatives
Herrero, M.Teresa,Tellitu, Imanol,Domínguez, Esther,Hernández, Susana,Moreno, Isabel,SanMartín, Raúl
, p. 8581 - 8589 (2007/10/03)
A new application of the hypervalent iodine reagent phenyliodine(III)bis(trifluoroacetate) (PIFA) has been developed for the construction of a series of N, O, S-containing heterocycle-fused quinolinone derivatives in a general and efficient way. An altern
