81447-37-2

Basic information

• Product Name: Benzenepropanoic acid, a-[[(4-methylphenyl)sulfonyl]oxy]-b-oxo-, ethyl ester
• CAS NO: 81447-37-2
• Molecular Formula: C18H18O6S
• Molecular Weight: 362.403
• Mol File: 81447-37-2.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, a-[[(4-methylphenyl)sulfonyl]oxy]-b-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, a-[[(4-methylphenyl)sulfonyl]oxy]-b-oxo-, ethyl ester(81447-37-2)
• EPA Substance Registry System: Benzenepropanoic acid, a-[[(4-methylphenyl)sulfonyl]oxy]-b-oxo-, ethyl ester(81447-37-2)

Safety Data

• Hazardous Substances Data: 81447-37-2(Hazardous Substances Data)

Upstream product

• 27126-76-7 [hydroxy(tosyloxy)iodo]benzene 
• 614-20-0 3-oxo-3-phenylpropionic acid 
• 75-05-8 acetonitrile 
• 104-15-4 toluene-4-sulfonic acid 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 371-11-9 4-(difluoroiodo)toluene 

Downstream Products

• 502935-47-9 2,4-diphenylthiazole-5-carboxylic acid 
• 402567-86-6 ethyl 2,4-diphenylthiazole-5-carboxylate 
• 3885-46-9 ethyl 3-(phenyl)quinoxaline-2-carboxylate 

Relevant articles and documents

Spiro cyclohexadienones from the reaction of phenolic enaminone derivatives with hypervalent iodine reagents

Phenolic enamino compounds, prepared from 2-(4-hydroxyphenyl)-ethylamine and the corresponding β-keto carbonyl compounds, afford spiro cyclohexadienone derivatives on reaction with hypervalent iodine reagents.

Oxidative umpolung ?±-alkylation of ketones

We disclose a hypervalent iodine mediated ?±-alkylative umpolung reaction of carbonyl compounds with dialkylzinc as the alkyl source. The reaction is applicable to all common classes of ketones including 1,3-dicarbonyl compounds and regular ketones via their lithium enolates. The ?±-alkylated carbonyl products are formed in up to 93% yield. An ionic mechanism is inferred based on meticulous analysis, NMR studies, trapping and crossover experiments, and computational studies.

THIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.